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THE ROLE OF THE CA1 PYRAMIDAL NEURON SPECIFIC MICROPEPTIDE CTXND1 IN ALZHEIMER'S DISEASE
Yingxuan Liand 1 co-author
Peking University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-593
Presentation
Date TBA
Board: PS04-08PM-593
Event Information
Poster Board
PS04-08PM-593
Poster
View posterAbstract
The hippocampus plays a crucial role in spatial memory, but the underlying molecular mechanisms require further exploration. In this study, we identified Ctxnd1 as a gene specifically expressed in the hippocampal CA1 pyramidal neuron with its decreased expression in Alzheimer’s disease in both mice and human. Both in vitro overexpression assays and in vivo detection by polyclonal antibody demonstrated that Ctxnd1 encodes a functional micropeptide, which is 59 amino acids long and is highly conserved in primates. Overexpression of Ctxnd1 in 5xFAD mice enhances their performance in both the Y-maze and Morris water maze tests. Additionally, we observed a significant reduction in Aβ plaque density in the brains of Ctxnd1-overexpressing 5xFAD mice. Calcium imaging revealed that overexpression of Ctxnd1 increases the spatial information of hippocampal CA1 place cells and enhances their ability to discriminate between distinct environments. In summary, this study suggests that the gene Ctxnd1, specifically expressed in the CA1 region of the hippocampus, may play an important role in hippocampal related spatial memory in Alzheimer's disease.
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