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SENSORY AUDITORY BEHAVIORAL DEFICIT IN A RAT MODEL OF DOWN SYNDROME
Davide Maggioniand 4 co-authors
University of Fribourg
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-525
Presentation
Date TBA
Board: PS07-10AM-525
Event Information
Poster Board
PS07-10AM-525
Poster
View posterAbstract
Down syndrome (DS) is a prevalent genetic cause of intellectual disability that also impacts auditory system function and sleep patterns. Here, we investigated auditory perception in a rat model of DS that carries a duplication of a segment of rat chromosome 20. In an auditory detection task, the rats were trained to release a lever after the onset of a narrow band sound, at 5 different amplitudes. For young animals around 6 months of age, detection performance (d prime) increased with sound amplitude for both DS and control groups, DS rats performed significantly worse, particularly at higher amplitudes (2-way ANOVA, p<0.05). Retesting both groups at age of 13 months, we found that DS rats reached the same performance as the control group (2-way ANOVA, p>0.1); an effect we attribute to auditory training by both groups during the intertest interval. Tracking of home cage activity of pair housed (DS-DS, WT-WT) rats over 24-hour periods revealed differences related to sleep pattern and locomotor aspects of behavior. These findings suggest the DS rat model recapitulates important aspects of human DS related to auditory perception.
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