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SINGLE-CELL TRANSCRIPTOMIC LANDSCAPE OF AGED DORSAL ROOT GANGLION REVEALS SPECIFIC NEURONAL LOSS AND MOLECULAR CHANGES WITH SOMATOSENSORY DECLINE
Kaikai Wangand 3 co-authors
Guangdong Institute of Intelligence Science and Technology
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-584
Presentation
Date TBA
Board: PS07-10AM-584
Event Information
Poster Board
PS07-10AM-584
Poster
View posterAbstract
Aging leads to a decline in somatosensation, but the mechanisms in the dorsal root ganglion (DRG) are not fully understood. This study aims to characterize the subtype-specific vulnerability of DRG neurons and explore the associated molecular drivers during aging. We performed single-cell RNA sequencing on DRGs from adult and aged mice, and integrated these findings with functional assessments. Our analysis revealed a selective reduction in the abundance of specific sensory neuron subtypes in aged mice. Transcriptomic profiling further indicated that these vulnerable neuronal populations exhibited significant dysregulation in cell apoptotic-related pathways. The alterations detected an imbalance between pro-survival and pro-apoptotic signals, which may contribute to their preferential loss. Besides, aging also led to the upregulation of pro-inflammatory genes and the downregulation of proteostasis- and RNA catabolism-related genes, collectively disrupting the expression of somatosensory molecules in DRG neurons. These insights into subtype-specific neuronal loss and related molecular basis may inform future strategies aimed at maintaining sensory function with aging.
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