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SINGLE NEURON CORRELATES OF EPISODIC MEMORY AND IMAGINATION IN THE HUMAN HIPPOCAMPUS AND AMYGDALA
Ezequiel León Saidmanand 4 co-authors
Hospital del Mar Medical Research Institute (IMIM)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-473
Presentation
Date TBA
Board: PS06-09PM-473
Event Information
Poster Board
PS06-09PM-473
Poster
View posterAbstract
Patients with hippocampal damage tend to exhibit a deficit not only in episodic memory but also in imagining fictional situations. In line with this evidence, non-invasive recordings have shown a key role of the Medial Temporal Lobe (MTL) in both episodic memory and imagination. However, the precise neural mechanisms supporting these processes remain largely unknown. To investigate this issue, we studied the activity of multiple single-neuron in patients candidates to epilepsy surgery that were implanted with intracranial electrodes for clinical reasons. The subjects performed a real-life memory and imagination paradigm, in which they were asked to recall and then imagine situations involving persons for which we had single neuron responses. Our results show a strong correlation between the firing of specific neurons with episodic memory and imagination. These results shed light onto the neuronal mechanisms underlying real-life memory and imagination in the human brain.
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