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THE TRANSLATIONAL FUNCTIONAL ARCHITECTURE OF CARDIOVASCULAR INTEROCEPTORS
Héloïse Policet-Betendand 1 co-author
University of Geneva
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-650
Presentation
Date TBA
Board: PS07-10AM-650
Event Information
Poster Board
PS07-10AM-650
Poster
View posterAbstract
Cardiovascular interoception plays a key role in emotional behavior. Its alteration has been linked to emotional dysregulation and anxiety. Cardiovascular states and blood composition are monitored by specialized receptors located in large vessels and the heart. However, it is unclear whether those receptors are altered in disease states linked to interoceptive dysregulation. In addition, their cellular and molecular structure is poorly characterized in humans. In this work we leveraged large scale human tissue clearing and multiplexed immunostaining to provide a detailed mapping of human cardiovascular interoceptors. We also traced their innervation to better understand the pathways linking them to the brain. Eventually, we studied with a similar approach equivalent structures in mice. Altogether, our data provides a detailed, functionally-relevant 3D cellular map of cardiovascular interoceptors in mice and humans which can serve as a base for mechanistic and translational research on interoception and interoceptive pathology.
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