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TRIP6 REGULATES NEURAL STEM CELL MAINTENANCE THROUGH THE NOTCH PATHWAY IN THE POSTNATAL MAMMALIAN SUBVENTRICULAR ZONE
Chia Chi Chungand 1 co-author
National Taiwan Normal University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-209
Presentation
Date TBA
Board: PS01-07AM-209
Event Information
Poster Board
PS01-07AM-209
Poster
View posterAbstract
Adult neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) pathway in the mammalian brain persists throughout life. Previously, we identified that an adaptor protein thyroid hormone receptor interacting protein 6 (TRIP6), is required for self-renewal and proliferation and inhibits neuronal differentiation in neural stem cells (NSCs) of the SVZ. The Notch pathway is also essential for NSC self-renewal and inhibits neuronal differentiation. Furthermore, we found that TRIP6 activated the Notch pathway. However, the mechanism underlying this process remains to be elucidated. With in vitro functional analysis, we found that TRIP6 promoted NSC self-renewal and inhibited neuronal differentiation through the Notch pathway. TRIP6 increased the level of the Notch intracellular domain (NICD) possibly through a post-translational manner in the Notch receptor processing. These results suggest that TRIP6 regulates NSC properties through Notch, providing a better understanding of the molecular mechanism of TRIP6 in NSC maintenance in the adult SVZ.
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