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VASCULAR AND MOLECULAR ALTERATIONS AS INDICATORS OF NEURODEVELOPMENTAL RISK IN MALE RAT OFFSPRING EXPOSED TO MATERNAL WESTERN DIET
Aniqa Saiyaraand 13 co-authors
Maj insitute of pharmacology polish academy of sciences
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-340
Presentation
Date TBA
Board: PS04-08PM-340
Event Information
Poster Board
PS04-08PM-340
Poster
View posterAbstract
The aim of this study was to determine whether early vascular and molecular alterations represent prodromal markers of neurodevelopmental disturbances in male offspring exposed to maternal Western diet (WD). Female Wistar Han rats were fed a control diet (CD) or a high-fat WD throughout gestation and lactation (14 wk). After weaning, male offspring were maintained on CD and assessed at postnatal days (PND) 30, 60, and 90. Behavioral screening included open field, novel object recognition, self-grooming, elevated zero maze, and social interaction with additional validated tests. Vascular function was evaluated in third-order mesenteric arteries using acetylcholine (ACH)-induced endothelium-dependent vasodilation, contractile responses to endothelin-1, blood pressure measurements, and morphometry. Additionally, RNA sequencing in the hippocampus (HIP) and prefrontal cortex (PFC) identified relevant genes, seven of which were validated at the protein level using ELISA. Maternal WD increased body weight and adiposity in male offspring and induced robust hyperlocomotion at PND30, accompanied by increased grooming and enhanced social interaction. The maximal endothelium-dependent vasodilation in response to ACh was reduced, with altered endothelin-1 responsiveness at PND30 and elevated systolic blood pressure at PND90, despite preserved vessel structure. Moreover, molecular analysis showed in the HIP reduced EDN1 at PND30, with increased KLF2 and decreased AGTRAP and eNOS at PND60, while VEGF-B was reduced at PND60 in the PFC. These findings indicate that maternal WD exposure induces early behavioral dysregulation in males, followed by age-dependent vascular changes associated with neurodevelopmental vulnerability.
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