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IN VIVO LIGHT-CONTROLLED NEUROINHIBITION OF FOCAL SEIZURES WITH PHOTOTHERAPORTS
Cristina Lópezand 8 co-authors
Institute of Biomedical Research of Barcelona (IIBB-CSIC)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-599
Presentation
Date TBA
Board: PS02-07PM-599
Event Information
Poster Board
PS02-07PM-599
Poster
View posterAbstract
Recent advances in chemistry and biophysics have enabled the development of light-based therapies as precise and minimally invasive strategies for the treatment of diverse medical conditions. In the PhotoTheraPort project, we combine locally light-emitting implants and light-controlled drugs to achieve neuroinhibitory treatments through photopharmacology. We aim to achieve spatially and temporally controlled neuromodulation for targeted therapeutic interventions, allowing neuronal activity to be modulated locally without systemic adverse effects. Proof-of-concept experiments are being performed in preclinical models of epilepsy, a neurological disorder characterized by recurrent seizures resulting from abnormal neuronal hyperexcitability. Despite available therapies, approximately 30% of patients remain resistant to current treatments. This project pursues two main objectives: (i) to assess the long-term safety and biocompatibility of the implanted devices in the brain, and (ii) to determine the efficacy of PhotoTheraPort-based modulation in attenuating seizure activity in vivo. Preliminary results indicate that preactivation of the photoswitchable drug significantly reduces epileptic activity compared to the non-preactivated compound, supporting the therapeutic potential of PhotoTheraPort as a safe and effective light-based strategy for localized neuromodulation in epilepsy.
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