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4,363 results
Recently, neurodegenerative diseases are more often linked with oral bacteria-driven infections. However, it is not clear how central nervous system pathologies root from infections of the oral cavity. Porphyromonas gingivalis (Pg) is a key-stone pathogen in periodontitis, a chronic inflammatory disease of the…
Compelling evidence supports that exploiting both patient-derived and animal models is pivotal to reach a better understanding of Parkinson’s disease (PD) (DOI:10.1002/mds.28387). However, working with in vivo models can be challenging as most of them only partially reproduce the pathology at advanced age.We recently…
This study explores the link between Autism Spectrum Disorder (ASD) and the transcriptional factor zinc finger and BTB domain-containing protein 20 (ZBTB20), known for its role in Primrose syndrome and ASD. We used a ZBTB20 haploinsufficient mouse model to demonstrate an autism-like phenotype, including impaired…
Long-term, stable access to brain function across scales enables the understanding of how brain organization evolves during development or aging. In large-brained animals, fMRI serves as a standard imaging option, albeit limited in its compatibility with other modalities that could probe activity at finer spatial and…
There is an active interest in torpor-like states for translational applications and the neural basis of torpor is presently a hot topic of research. Activation of Esr1-expressing preoptic area neurons generates torpor-like states, suggesting a link between hormonal status and torpor. This is an important…
Anxiety, a heightened state of arousal and negative affect, is an adaptive response essential for increasing awareness of potential threats in the environment. Research on the mechanisms leading to the pathological development of this response is crucial. The ventral tegmental area (VTA) is recognized as a key brain…
Optogenetics is an invaluable technique in neuroscience to study brain circuits. However, conventional optogenetic systems for rodents use optical fibers tethered to steady-state lasers to deliver light to the brain, which increases animal’s anxiety and hinders natural behavior. Therefore, we developed a novel…
Wobble board-based Exergaming of different intensities provides a unique approach to enhance different cognitive and balance parameters . This study aims to determine that which of the cognitive and balance components are greatly affected by wobble board exergaming of different intensities in individuals with mild…
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Manipulating neuronal activity in the central nervous system through electrical stimulation is crucial for the clinical treatment of neurological disorders and for basic neuroscience research. Traditional electrode implantations might carry the risk of complications, infection, and damage caused by micromovements…
Sharing a common ancestor that lived approximately 320 million years ago, avian and mammalian lineages have independently developed seemingly different pallial structures that nonetheless support comparable cognitive functions. Investigating analogous functional architectures in avian brains presents a challenging yet…
Neuronal activation throughout the cortex correlates strongly with the animal’s movement. Movement-related cortical activity in the sensory areas is thought to function as corollary discharge and to modulate sensory processing during self-generated motor activity. However, the exact role, neuronal circuits, and…
Knowledge of the timing of events is critical for efficient behaviour. Previous work examining the formation of expectations following temporally predictable stimulus sequences has revealed that humans are able to extract regularities, which can improve performance. To determine the underlying neural circuits that…
Fragile X syndrome (FXS), caused by inactivation of Fmr1 gene, is the most common cause of intellectual disability and autism spectrum disorder. Fmr1 knockout (Fmr1KO) mice display a disorganization of perineuronal nets (PNNs), specialized forms of extracellular matrix which form around neurons during postnatal…
The dynamic role of neuroinflammation in diverse neurological disorders is still poorly characterized but could represent a promising avenue for therapeutic interventions. Here we aimed at characterizing brain-wide response of microglia to ischemic stroke in mouse. Microglia, the frontline responders to ischemic…
Both classical activity mapping based on the induction of activity-regulated genes and novel genetic methods to label and control the activity of neurons indicate that memories are deposited in discrete neuronal ensembles in the hippocampus, amygdala and other brain regions involved in memory formation. However, the…
The discovery of LSD launched a new era of psychedelic research. The number of clinical trials is consistently increasing since psychedelics' sustained therapeutic effects seem to be promising in the reduction of symptoms of various neuropsychiatric disorders. In humans, the acute neuronal effect of psychedelics is…
Anxiety and mood disorders significantly impact individual well-being and societal health, highlighting the need for a thorough understanding of their risk factors. While early life stress is widely recognized as a risk factor for multiple psychiatric conditions, the neurobiological mechanisms driving these effects…
The ability to switch between different behaviors is essential to all animals’ survival. The selection of a behavior is guided by multiple factors, such as sensory inputs, internal states, and memory, which suggests that regions across the brain are involved in the decision to switch between them. While whole-brain…
The idea that evidence accumulation is the only crucial factor for decision making has been recently challenged. Even during simple visual tasks, both impulsivity/prudence and working memory (WM) may also play a crucial role in its dynamics. We wanted to investigate how a wide range of sequences of visual evidence and…
Excessive capillary flow heterogeneity results in a microcirculatory dysfunction and hinders optimal oxygen delivery into central nervous system (CNS). Irregularities in cellular flow, like dynamic stalls in capillaries is a potential origin of this heterogeneity. Because under systemic inflammatory conditions…
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, closely linked to the loss/gain of astrocytic function. Using the ALS…
Previous research has shown that the N1 responses are attenuated for sensory consequences of self-initiated actions compared to externally-initiated sensory consequences. This illustrates the existence of prediction mechanisms allowing the differentiation between self and externally generated events. Previous studies…
Lactate is an important metabolite produced by astrocytes and delivered to neurons to support their energy needs in a process known as the astrocyte-neuron lactate shuttle. Emerging research during the past decade has unveiled a role of lactate as a signal capable of orchestrating critical functions ranging from…
In their daily life, humans and other animals continuously face the need to quickly remember what to do in familiar contexts and how to do it. Generally, the basal ganglia, and more specifically the dorsal striatum (dStr), are believed to be implicated in high-level functions (storage of procedural memories and/or…