Doctoral Student in High-throughput Analysis of Protein-Protein Interactions

Develop high-throughput methods to measure how protein interactions respond to mechanical force. The project combines protein engineering, yeast surface display, directed evolution, deep sequencing and single-molecule force measurements, with machine-learning models trained on the resulting data. Initial applications study interactions involved in blood clotting and von Willebrand disease. This salaried doctoral appointment spans experimental and computational work at ETH Zurich and the University of Basel, with teaching and publication duties.

Master’s degree in bioengineering, chemical engineering, biochemistry, molecular biology, biophysics or a related discipline. Quantitative skills, molecular-biology or protein-expression experience, fluent English and eligibility for the D-BSSE doctoral programme.