Ethan Goldberg

A postdoctoral fellowship position is available to study mechanisms genetic epilepsies of childhood in experimental model systems. The lab studies ion channel variants expressed in heterologous systems; neurons and organoids derived from human embryonic stem cells from human patients; cell profiling/transcriptomics; cellular neurophysiology and synaptic transmission in acute brain slices prepared from mice; and 2P calcium imaging and electrophysiology in awake, behaving experimental animals.

Recent graduate with a Ph.D. in Neuroscience or applied field (electrical or biomedical engineering; computer science; cellular and molecular biology). Prior experience with electrophysiology, imaging, transcriptomics, and/or computational neuroscience, is preferred.

Recent publications from the lab include:
-- Favero, M., Sotuyo, N.P., Lopez, E., Kearney, J.A., Goldberg, E.M. : A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of Dravet syndrome. The Journal of Neuroscience 38(36): 7912-7927, September 2018. PMCID: PMC6125809
-- Goff, K.M., Goldberg, E.M.: Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet Syndrome. Elife July 2019. PMCID: PMC6629374
-- Tran, C.H., Vaiana, M., Nakuci, J., Somarowthu, A., Goff, K.M., Goldstein, N., Murthy, P., Muldoon, S.F., Goldberg, E.M.: Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome. Journal of Neuroscience 40(13): 2764-2775, May 2020. PMCID: PMC7096149
-- Zaman, T., Helbig, K.L., Clatot, J., […] Goldberg, E.M. : SCN3A-related neurodevelopmental disorder: A spectrum of epilepsy and brain malformation. Ann Neurol doi: 10.1002/ana.25809, Online ahead of print 2020.