“Integration of visual and behavioural signals in the early visual system”

In this project, you will discover how retinal, cortical and neuromodulatory inputs shape the responses of visual neurons in the superior colliculus. The goal of your Phd project is to understand the mechanisms of signal integration, i.e. which inputs to the superior colliculus shape its neural activity, and the advantages of this integration for visual processing.

You will use two-photon imaging in awake mice to simultaneously record activity of neurons in the superior colliculus as well as of axons originating in the retina, visual cortex, or brainstem nuclei such as the dorsal raphe (serotonin). You will compare the responses of the axonal inputs to those in the neurons, and you will observe how these signals change depending on the visual input and the behaviour of the animal.

In the beginning of your project, you will develop an advanced imaging technique in collaboration with our industrial partner, Scientifica. You will adapt the existing two-photon microscope to image two separate fields of view simultaneously. This technique, termed multi-region imaging, will enable you to record inputs and outputs of superior colliculus at sufficient detail, speed, and quantity.