Post-DocApplications Closed

Prof. Simon Fisher

Unknown Organization

Nijmegen, Netherlands

Apply by Jun 30, 2021

Application deadline

Jun 30, 2021

Job

Job location

Prof. Simon Fisher

Geocoding

Nijmegen, Netherlands

Geocoding in progress.

Source: legacy

Quick Information

Application Deadline

Jun 30, 2021

Start Date

Flexible

Education Required

See description

Experience Level

Not specified

Job

Job location

Prof. Simon Fisher

Geocoding

Nijmegen, Netherlands

Geocoding in progress.

Source: legacy

Map

Job Description

Through whole genome DNA sequencing, we have identified rare gene disruptions that cause speech and language impairments in human neurodevelopmental disorders. The successful candidate will lead specific projects within an ongoing research programme that investigates the neurobiological consequences of such gene disruptions (in FOXP1/2/4, CHD3, SETBP1 among other genes). This programme adopts the latest human cell-culture techniques (stem-cell derived 2D and 3D neuronal models), CRISPR/Cas-based gene editing, single-cell RNA sequencing, and other state-of-the-art methods.

Requirements

You are a research scientist who holds
or shortly expects to obtain
a PhD in a field that has given you extensive wet-laboratory experience
including hands-on work with human cell-culture models. Expertise in a range of molecular and cell biological methods is essential. Previous experience with generating and characterizing 2D neuronal cultures or brain spheroids/organoids is highly desirable. Familiarity or experience with gene-editing (e.g. via CRISPR/Cas)
single-cell sequencing
assays of neuronal properties (e.g. differentiation and maturation
morphology
activity) and/or calcium imaging will be an advantage. You have a critical and careful approach to laboratory work and record keeping
and you strive for robustness and reproducibility of results. You are adept in communicating project plans and outcomes to others
in both spoken and written form. The successful candidate will be involved in supervising junior scientists
including students and research assistants
and writing up findings for publication
as well as giving presentations about the work at international conferences.

Job