The Smith lab is seeking a team members to conduct exciting research in human neurodevelopment and models of neuronal activity in the prenatal brain. Interested applicants can expect to work in an environment that promotes autonomy and all the resources to develop and expand the several ongoing research projects of the lab. These include, but are not limited to, questions relating to human brain development, human disease modeling (using high throughput approaches), and therapeutics. Current NIH funded projects are examining ion flux and biophysical properties of developing cell types in the prenatal brain, specifically as is relates to childhood diseases.

As a trainee you will have to opportunity gain expertise in several state-of the art approaches widely used to interrogate important aspects of neurodevelopment, including human stem cell cerebral organoid models, single cell sequencing (RNA/ATAC), high-content confocal microscopy/screening, ferret model of cortex development and hiPSC derived neuronal models (excitatory, dopamine, inhibitory). Additional physiology approaches include, 2-photon imaging, high-throughput electrophysiology, patch-clamp, and calcium/voltage imaging.

Please visit our website for details about our research, www.rsmithlab.com