Research Assistant (R1), Department of Neurogenetics and Functional Genomics: Alzheimer's disease brain organoids

The Mossakowski Medical Research Institute, Polish Academy of Sciences (MMRI PAS) in Warsaw is recruiting a full-time research assistant (R1, master's level) for its Department of Neurogenetics and Functional Genomics. The department studies the mechanisms of familial Alzheimer's disease with a focus on synaptic dysfunction in reprogrammed human neurons and brain organoids, characterises mutations and genomic variants in neurodegenerative, muscular, neurodevelopmental and neuropsychiatric disorders, analyses mitochondrial function and mitophagy in frontotemporal dementia caused by PGRN, MAPT and C9orf72 mutations, and develops iPSC models from patients with PSEN1/2 mutations.

The assistant will run 2D human neuron and 3D brain organoid cultures, derive new patient models from primary fibroblasts through reprogramming, carry out functional studies of synaptic and epigenetic markers and multi-omic studies of early Alzheimer's disease, assist with whole-cell patch-clamp, microelectrode-array and calcium-imaging recordings, help build a brain-organoid platform for translational research, and publish and present results. Applications in PDF, addressed to the Director and quoting job offer number SDI.111.13.2026, must be received by email by the deadline; results are expected in December 2026 and the post starts in January 2027.

Master's degree or equivalent in biological or medical sciences; authored or co-authored publications; in vitro cell culture, molecular biology and confocal microscopy; good knowledge of bioinformatics and statistical analysis; MMRI PAS as primary employer; good or very good English and communicative Polish. Desirable: organoid culture and electrophysiological measurement experience.