ePoster
TPH2 knockout rats cannot accept social defeat in resident-intruder test
Ilya Zhukov, Vsevolod Nemets, Yazen Alnefeesi, Petr Shabanov and 2 more
Video and audio
FENS Forum 2024
Brain serotonin (5-HT) is one of the key regulators of aggressive behavior and social defeat stress mechanisms. We had previously found that abolishing central 5-HT biosynthesis increases aggression, as tryptophan hydroxylase 2 (Tph2-/-) knockout rats (TPH2-KO) are more aggressive than wild-type (WT) counterparts. In…
Serotonin (5-HT)aggressive behaviorsocial defeat stress