Regenerative Medicine podcasts

This Nature Podcast episode examines human brain organoids transplanted into mice lacking a cerebral cortex, where extensive cellular integration could create an in-vivo platform for testing therapies and studying human neurobiology. It also covers research highlights and Paper2Agent, an AI system that turns research papers into interactive virtual corresponding authors able to answer questions and support complex scientific tasks.

Thomas Reh and Juliette Wohlschlegel discuss their research on converting human Müller glia into retinal neurons with host Martin Pera. The conversation traces how regeneration in fish and frogs motivated experiments in mammals, then examines genetic reprogramming of cells derived from human fetal tissue or retinal organoids. Their study of ASCL1-induced neurogenesis provides a basis for discussing the remaining biological and translational challenges of retinal regeneration. The work concerns experimental cellular models and does not establish a treatment for vision loss.