Circuit homeostasis: keeping a level head when the brain gets hot
Friday, April 23, 2021
06:00 UTC
Dr. Michelle Antoine
NIH
Recording
Open recording
Hosted by NYU Swartz70 minutes
Abstract
Core body temperature is regulated to a setpoint between 36.1 to 37.8°C, with an average fluctuation of 0.5°C during a 24-hour day. Despite mechanistic safeguards, major temperature deviations (1-3°C) from the setpoint occur in the body and in turn the brain. For unknown reasons, in most mammals (humans included), these increases in brain temperature are benign. However, macro-fluctuations in brain temperature in some cases result in deleterious outcomes such as seizures. In this talk, I will describe a mechanism for circuit-level adaptive regulation of cortical activity during macro-fluctuations in brain temperature. I will also discuss how this mechanism can be applied towards the understanding of the pathology of Autism Spectrum Disorder.
Topics
Related Seminars
SeminarSeminarSeminar
Finding Meaning in Memories
Daphna Shohamy and Ashok Litwin-Kumar bridge experimental and computational neuroscience to explain how the brain assigns significance to memories, how dopamine shapes memory-guided decisions, and…
Upcoming · Sep 16, 2026
Columbia University Zuckerman Institute
Deciphering the Dynamics of the Unconscious Brain under General Anesthesia
Stanford Neurosciences Seminar Series talk by Emery Brown (Massachusetts Institute of Technology, Neuroscience Statistics Research Lab) on deciphering the dynamics of the unconscious brain under…
Upcoming · Sep 17, 2026
Wu Tsai Neurosciences Institute, Stanford University
The Connectome in Use: From anatomical wiring to functional organization in the behaving C. elegans brain
Rani Borbara presents brain-wide recordings from more than 150 freely moving C. elegans to examine how anatomical connectivity becomes functional organization during behavior. Cross-animal models…
Upcoming · Sep 18, 2026
MIT Simons Center for the Social Brain
Related Job Opportunities
JobJobJob
PhD Studentship: Mitochondrial Metabolism and Novel Therapeutic Strategies for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (Fixed Term)
Supervisors: Professor Andrew Murray, Department of Physiology, Development and Neuroscience, University of Cambridge Dr Ross Lindsay, Novo Nordisk Funding: Fully funded PhD studentship (Home/UK…
Posted Aug 10, 2026
Postdoctoral Scientist - Sarvestani Lab
The Sarvestani Lab at Cornell University is recruiting a postdoctoral scientist in systems neuroscience to study how visual and motor systems across the brain and body support perception and…
Posted Aug 12, 2026
Ithaca, New York, United States
ARISE2 Postdoctoral Fellowship - 2026 Call for Applications
EMBL's ARISE2 programme offers more than 20 fully funded, three-year postdoctoral fellowships for scientists developing research-infrastructure technologies across the life sciences, including…
Posted Aug 12, 2026
Multiple EMBL sites in Europe