Circuit homeostasis: keeping a level head when the brain gets hot
Schedule
Friday, April 23, 2021
06:00 UTC
Michelle Antoine
Dr.
NIH
Host: NYU Swartz
Recording
Open recording
Event Information
Recording
Available
Host
NYU Swartz
Duration
70 minutes
Abstract
Core body temperature is regulated to a setpoint between 36.1 to 37.8°C, with an average fluctuation of 0.5°C during a 24-hour day. Despite mechanistic safeguards, major temperature deviations (1-3°C) from the setpoint occur in the body and in turn the brain. For unknown reasons, in most mammals (humans included), these increases in brain temperature are benign. However, macro-fluctuations in brain temperature in some cases result in deleterious outcomes such as seizures. In this talk, I will describe a mechanism for circuit-level adaptive regulation of cortical activity during macro-fluctuations in brain temperature. I will also discuss how this mechanism can be applied towards the understanding of the pathology of Autism Spectrum Disorder.
Topics
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