Computational modelling of neurotransmitter release
Schedule
Wednesday, May 18, 2022
05:00 UTC
Yulia Timofeeva
University of Warwick
Host: van Vreeswijk TNS
Recording
Open recording
Event Information
Recording
Available
Host
van Vreeswijk TNS
Duration
70 minutes
Abstract
Synaptic transmission provides the basis for neuronal communication. When an action-potential propagates through the axonal arbour, it activates voltage-gated Ca2+ channels located in the vicinity of release-ready synaptic vesicles docked at the presynaptic active zone. Ca2+ ions enter the presynaptic terminal and activate the vesicular Ca2+ sensor, thereby triggering neurotransmitter release. This whole process occurs on a timescale of a few milliseconds. In addition to fast, synchronous release, which keeps pace with action potentials, many synapses also exhibit delayed asynchronous release that persists for tens to hundreds of milliseconds. In this talk I will demonstrate how experimentally constrained computational modelling of underlying biological processes can complement laboratory studies (using electrophysiology and imaging techniques) and provide insights into the mechanisms of synaptic transmission.
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