How do parasites evade immune clearance? A structural perspective

Parasites persist despite continual exposure to immune molecules and cells. African trypanosomes live in serum and tissues, while intracellular parasites such as malaria parasites display their own proteins on host cells. This seminar examines how parasites avoid detection and clearance through antigenic variation and surface proteins that suppress immune cells or their effectors. It also considers the experimental and computational approaches used to investigate these mechanisms, showing the diversity of adaptations that permit parasites to resist immunity. The presentation is intended for students and researchers interested in infection, immunity and evolution; undergraduate biology is helpful.