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Nencki Institute of Experimental Biology
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Schedule
Wednesday, March 17, 2021
1:30 PM Europe/London
Domain
NeuroscienceHost
Transatlantic Systems Neuro
Duration
70 minutes
Working memory (WM) is a fundamental human cognitive capacity that allows us to maintain and manipulate information stored for a short period of time in an active form. Thanks to a unique opportunity to record activity of neurons in humans during epilepsy monitoring we could test neuronal mechanisms of this cognitive capacity. We showed that firing rate of image selective neurons in Medial Temporal Lobe persists through maintenance periods of working memory task. This activity was behaviorally relevant and formed attractors in its state-space. Furthermore, we showed that firing rate of those neurons phase lock to ongoing slow-frequency oscillations. The properties of phase locking are dependent on memory content and load. During high memory loads, the phase of the oscillatory activity to which neurons phase lock provides information about memory content not available in the firing rate of the neurons.
Jan Kamiński
Nencki Institute of Experimental Biology
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