An inconvenient truth: pathophysiological remodeling of the inner retina in photoreceptor degeneration
Tuesday, April 8, 2025
16:00 UTC
Dr Michael Telias
University of Rochester
Recording
Open recording
Hosted by BIU Vision Science70 minutes
Abstract
Photoreceptor loss is the primary cause behind vision impairment and blindness in diseases such as retinitis pigmentosa and age-related macular degeneration. However, the death of rods and cones allows retinoids to permeate the inner retina, causing retinal ganglion cells to become spontaneously hyperactive, severely reducing the signal-to-noise ratio, and creating interference in the communication between the surviving retina and the brain. Treatments aimed at blocking or reducing hyperactivity improve vision initiated from surviving photoreceptors and could enhance the signal fidelity generated by vision restoration methodologies.
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