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University of Edinburgh
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Schedule
Wednesday, October 12, 2022
7:35 PM Europe/Berlin
Recording provided by the organiser.
Domain
NeuroscienceHost
WWNeuRise
Duration
35 minutes
Standard models of episodic memory suggest that lateral (LEC) and medial entorhinal cortex (MEC) send independent inputs to the hippocampus, each carrying different types of information. Here, we describe a pathway by which information is integrated between LEC and MEC prior to reaching hippocampus. We demonstrate that LEC sends strong projections to MEC arising from neurons that receive neocortical inputs. Activation of LEC inputs drives excitation of hippocampal-projecting neurons in MEC layer 2, typically followed by inhibition that is accounted for by parallel activation of local inhibitory neurons. We therefore propose that local circuits in MEC may support integration of ‘what’ and ‘where’ information.
Brianna Vandrey
University of Edinburgh
neuro
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