Lateral entorhinal cortex directly influences medial entorhinal cortex through synaptic connections in layer 1
Schedule
Wednesday, October 12, 2022
17:35 UTC
Brianna Vandrey
University of Edinburgh
Host: WWNeuRise
Recording
Open recording
Event Information
Recording
Available
Host
WWNeuRise
Duration
35 minutes
Abstract
Standard models of episodic memory suggest that lateral (LEC) and medial entorhinal cortex (MEC) send independent inputs to the hippocampus, each carrying different types of information. Here, we describe a pathway by which information is integrated between LEC and MEC prior to reaching hippocampus. We demonstrate that LEC sends strong projections to MEC arising from neurons that receive neocortical inputs. Activation of LEC inputs drives excitation of hippocampal-projecting neurons in MEC layer 2, typically followed by inhibition that is accounted for by parallel activation of local inhibitory neurons. We therefore propose that local circuits in MEC may support integration of ‘what’ and ‘where’ information.
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