Lateral entorhinal cortex

…map's construction, with the Medial Entorhinal Cortex (MEC) encoding self-motion cues (Path Integration) analogous to the 'where' pathway, while the Lateral Entorhinal Cortex (LEC) integrates sensory inputs analogous to the 'what' pathway. Object-dependent spatial cells, including Object Vector cells, Object Sensitive

…spatial relationships within the lateral entorhinal cortex (LEC), the downstream circuitry and mechanisms orchestrating these behaviors remain elusive. Similarly, significant progress has been made in uncovering amygdala circuit-level mechanisms for defensive and appetitive behaviors, yet integrating spatial object information within specific amygdala circuits remains a puzzle. To address these gaps, we unveil a com

Memories are thought to be stored as material changes occurring in sparse, widely distributed populations of neurons known as engrams. This neural plasticity is theorised to promote re-activation of this network of engram cells upon re-exposure to relevant cues, thus leading to memory retrieval. Significant evidence exists to support this theory in relation to highly aversive or rewarding experiences, however less evidence exists to support the existence of engrams for day-to-day learning experiences. Here we used TRAP2 mice to characterize expression patterns and plasticity in neurons activat

…activity of neural populations in the lateral entorhinal cortex (LEC). However, whether or how this code for episodic time is integrated with the spatial codes in the hippocampus remains to be determined. To answer this question, we implanted high-density silicon probes in the hippocampal CA1 region and LEC in mice. Activity in the two regions was simultaneously recorded while mice were either freely foraging in an open field arena or head-fixed runn

…information, arriving from medial entorhinal cortex (MEC), and object information, arriving from lateral entorhinal cortex (LEC), are integrated within the hippocampus. However, we recently discovered that fan cells in the LEC send direct projections to MEC, suggesting that spatial and object information could be integrated within MEC (Vandrey et al. 2022, doi:10.7554/eLife.83008). Evidence for object-related firing in the MEC is consistent with this possibility, but whether LEC projections influence spatial and obje

…The lateral entorhinal cortex may play a key role due its convergence of multisensory inputs, its encoding of events and their temporal relationships, and its connections with the hippocampal memory system. Here, we simultaneously recorded hundreds to thousands of neurons from lateral entorhinal cortex (LEC), media

…entrainment of the downstream lateral entorhinal cortex (LEC) and hippocampus (HP). The tight anatomical connections between olfactory system and higher-order neuronal circuits might implicate the functional impact of olfactory outputs on cognitive functions along brain development. However, it is unclear whether early OB activity h

…dependent on the medial prefrontal cortex (mPFC) at remote time-points. Although the retrieval-induced activity of mPFC increases with time, it is unclear whether distinct mPFC projection-specific populations (PSPs) contribute to retrieval at different time points. Here, delineate how these distinct PSPs contribute to memory expression at recent vs. remote time-points. We virally labeled PSPs and examined the extent to which they are reactivated during recent vs. remote recall. Then, we used optogene

The entorhinal cortex (EC) is central to the brain’s navigation system. Its subregions are conventionally thought to compute dichotomous representations for spatial processing: medial entorhinal cortex (MEC) provides a global spatial map, while lateral entorhinal cortex (LEC) encodes specific sensory details of experience. While local recordings of EC circuits have amassed a vast catalogue of specialized cell types that could support navigation computations in the brain, we have little direct evidence for how these signals are actually transmitted outside of the EC to its primary downstream re

…in cells of the hippocampus and entorhinal cortex, which carry information about the animal’s location in an environment. These representations are adaptable to changes in the environment; for example, the number of hippocampal place cells that encode a particular location will increase if a reward is delivered at that location. We aimed to investigate what information the two regions of the entorhinal cortex – medial and lateral – may contribute during reward-guided spat

…such as the hippocampus (HP) and lateral entorhinal cortex (LEC). They are modulated by multiple sensory systems. During development, the olfactory system might have a particular impact on these areas in mice that at birth are blind, deaf, do not whisker and have poor motor abilities. We previously showed that neonatal olfactory activation boosts the oscillatory entrainment of LEC via mono-and polysynaptic projections from the olfactory bulb (OB). However, the long-lasting impact of olfactory

This seminar is part of our “Emergent Scientists” series, an initiative that provides a platform for scientists at the critical PhD/postdoc transition period to share their work with a broad audience and network. Summary: These talks cover Alzheimer’s disease (AD) research in both mice and humans. Christiana will discuss in particular the translational aspects of applying mouse work to humans and the importance of timing in disease pathology and intervention (e.g. timing between AD biomarkers vs. symptom onset, timing of therapy, etc.). Siddharth will discuss a rare variant of Alzheimer’s dise