World Wide relies on analytics signals to operate securely and keep research services available. Accept to continue, or leave the site.
Review the Privacy Policy for details about analytics processing.
Dr
Imperial College
Showing your local timezone
Schedule
Thursday, September 23, 2021
4:00 PM Australia/Sydney
Seminar location
No geocoded details are available for this content yet.
Recording provided by the organiser.
Format
Recorded Seminar
Recording
Available
Host
Sydney Systems Neuroscience and Complexity SNAC
Seminar location
No geocoded details are available for this content yet.
Networks are widely used as mathematical models of complex systems across many scientific disciplines, and in particular within neuroscience. In this talk, we introduce two aspects of our collaborative research: (1) machine learning and networks, and (2) graph dimensionality. Machine learning and networks. Decades of work have produced a vast corpus of research characterising the topological, combinatorial, statistical and spectral properties of graphs. Each graph property can be thought of as a feature that captures important (and sometimes overlapping) characteristics of a network. We have developed hcga, a framework for highly comparative analysis of graph data sets that computes several thousands of graph features from any given network. Taking inspiration from hctsa, hcga offers a suite of statistical learning and data analysis tools for automated identification and selection of important and interpretable features underpinning the characterisation of graph data sets. We show that hcga outperforms other methodologies (including deep learning) on supervised classification tasks on benchmark data sets whilst retaining the interpretability of network features, which we exemplify on a dataset of neuronal morphologies images. Graph dimensionality. Dimension is a fundamental property of objects and the space in which they are embedded. Yet ideal notions of dimension, as in Euclidean spaces, do not always translate to physical spaces, which can be constrained by boundaries and distorted by inhomogeneities, or to intrinsically discrete systems such as networks. Deviating from approaches based on fractals, here, we present a new framework to define intrinsic notions of dimension on networks, the relative, local and global dimension. We showcase our method on various physical systems.
Robert Peach and Alexis Arnaudon
Dr
Imperial College
neuro
neuro
The development of the iPS cell technology has revolutionized our ability to study development and diseases in defined in vitro cell culture systems. The talk will focus on Rett Syndrome and discuss t
neuro
Pluripotent cells, including embryonic stem (ES) and induced pluripotent stem (iPS) cells, are used to investigate the genetic and epigenetic underpinnings of human diseases such as Parkinson’s, Alzhe