Medial Septal GABAergic Neurons Reduce Seizure Duration Upon Wireless Optogenetic Closed-Loop Stimulation
Schedule
Wednesday, August 19, 2020
16:00 UTC
Alfredo Gonzalez-Sulser
Dr
University of Edinburgh
Host: Clinical and Experimental Epilepsy
Recording
Open recording
Event Information
Recording
Available
Host
Clinical and Experimental Epilepsy
Duration
70 minutes
Abstract
Seizures can emerge from multiple or large foci in temporal lobe epilepsy (TLE), complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenetic techniques. Here, we evaluate a strategy in which optogenetic activation of medial septal GABAergic neurons (MSGNs), which provide extensive projections throughout the hippocampus, is used to control seizures. We found that MSGNs were structurally and functionally resilient in the chronic intrahippocampal kainate mouse model of TLE, which as is often the case in human TLE patients, presents with hippocampal sclerosis. Optogenetic stimulation of MSGNs modulated oscillations across the rostral to caudal extent of the hippocampus in epileptic conditions. Chronic wireless optogenetic stimulation of MSGNs, upon electrographic detection of spontaneous hippocampal seizures, resulted in reduced seizure durations. We propose MSGNs as a novel target for optogenetic control of seizures in TLE.
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