More than a beast growing in a passive brain: excitation and inhibition drive epilepsy and glioma progression
Schedule
Wednesday, April 12, 2023
18:00 UTC
Gilles Huberfeld
Prof
Hôpital Fondation Adolphe de Rothschild
Host: Clinical and Experimental Epilepsy
Recording
Open recording
Event Information
Recording
Available
Host
Clinical and Experimental Epilepsy
Duration
70 minutes
Abstract
Gliomas are brain tumors formed by networks of connected tumor cells, nested in and interacting with neuronal networks. Neuronal activities interfere with tumor growth and occurrence of seizures affects glioma prognosis, while the developing tumor triggers seizures in the infiltrated cortex. Oncometabolites produced by tumor cells and neurotransmitters affect both the generation of epileptic activities by neurons and the growth of glioma cells through synaptic-related mechanisms, involving both GABAergic / Chloride pathways and glutamatergic signaling. From a clinical sight, epilepsy occurrence is beneficial to glioma prognosis but growing tumors are epileptogenic, which constitutes a paradox. This lecture will review how inhibitory and excitatory signaling drives glioma growth and how epileptic and oncological processes are interfering, with a special focus on the human brain.
Topics
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