Motion processing across visual field locations in zebrafish

Abstract

Animals are able to perceive self-motion and navigate in their environment using optic flow information. They often perform visually guided stabilization behaviors like the optokinetic (OKR) or optomotor response (OMR) in order to maintain their eye and body position relative to the moving surround. But how does the animal manage to perform appropriate behavioral response and how are processing tasks divided between the various non-cortical visual brain areas? Experiments have shown that the zebrafish pretectum, which is homologous to the mammalian accessory optic system, is involved in the OKR and OMR. The optic tectum (superior colliculus in mammals) is involved in processing of small stimuli, e.g. during prey capture. We have previously shown that many pretectal neurons respond selectively to rotational or translational motion. These neurons are likely detectors for specific optic flow patterns and mediate behavioral choices of the animal based on optic flow information. We investigate the motion feature extraction of brain structures that receive input from retinal ganglion cells to identify the visual computations that underlie behavioral decisions during prey capture, OKR, OMR and other visually mediate behaviors. Our study of receptive fields shows that receptive field sizes in pretectum (large) and tectum (small) are very different and that pretectal responses are diverse and anatomically organized. Since calcium indicators are slow and receptive fields for motion stimuli are difficult to measure, we also develop novel stimuli and statistical methods to infer the neuronal computations of visual brain areas.

Motion processing across visual field locations in zebrafish

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