The Neandertal Genome and the Evolution of Modern Humans — Svante Pääbo

Svante Pääbo explains how DNA recovered from ancient remains opened an experimental route to studying extinct human relatives. The lecture follows the technical challenge of extracting reliable genetic information from small, degraded and contaminated samples, through the reconstruction of Neanderthal genomes and the identification of Denisovans. Comparisons with living people reveal interbreeding between archaic hominins and the ancestors of present-day humans. Pääbo connects those findings to questions about human origins, the genetic changes that distinguish modern humans, and the continuing biological effects of inherited archaic variants. The account shows how methodological advances in paleogenomics changed both the history of human populations and the questions that can be asked about human biology.