Novel Tools for Spatial and Temporal Genomics
Monday, November 23, 2020
11:00 UTC
Dr Fei Chen
Broad Institute
Recording
Open recording
Hosted by Imperial Centre for Neurotechnology70 minutes
Abstract
The precise spatial localization of molecular signals within tissues richly informs the mechanisms of tissue formation and function. Here, we’ll introduce Slide-seq, a technology which enables transcriptome-wide measurements with near-single cell spatial resolution. We’ll describe recent experimental and computational advances to enable Slide-seq in biological contexts in biological contexts where high detection sensitivity is important. More broadly, we’ll discuss the promise and challenges of spatial transcriptomics for tissue genomics. Lastly, we’ll touch upon novel molecular recording technologies, which allows recording of the absolute time dynamics of gene expression in live systems into DNA sequences.
Topics
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