Cookies
We use essential cookies to run the site. Analytics cookies are optional and help us improve World Wide. Learn more.
Dr
Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden- Rossendorf (HDZR), Germany
Showing your local timezone
Schedule
Thursday, October 13, 2022
8:30 AM Australia/Melbourne
Domain
NeuroscienceHost
Ad hoc
Duration
70 minutes
Bispidines (3,7-diazabicyclo[3.3.1]nonane) and their derivatives act as bifunctional chelators (BFC), combining the advantages of multidentate macrocyclic and acyclic ligands e.g. high kinetic inertness, rapid radiolabelling under mild conditions. This bicyclic chelator system shows a great diversity in terms of its denticity and type of functional groups, yielding a wide range of multidentate ligands that can bind a variety of different metal ions. In addition, they allow a facile functionalisation of targeting molecules such as peptides, peptidomimetics, and bispecic antibodies. Herein, examples of various bispidine complexes labelled with [64Cu]Cu2+, [111In]In3+, [ 177Lu]Lu3+ or [ 225Ac]Ac3+ will be presented which provide a picture of how different substituents inuence the coordination mode. Target-specic radiolabelled bispidine-based conjugates (e.g. peptides, antibody fragments, antibodies) investigated in vivo by positron emission or single-photon emission computed tomography will be presented and discussed in terms of their suitability for nuclear medicine applications.
Manja Kubeil
Dr
Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden- Rossendorf (HDZR), Germany
neuro
Nervous system function relies on the polarized architecture of neurons, established by directional transport of pre- and postsynaptic cargoes. While delivery of postsynaptic components depends on the
neuro
A combinatorial neural code for long-term motor memory
neuro
The postdoctoral researcher will work on an interdisciplinary project at the intersection of deep learning and comparative politics. The candidate will work in the Human-Centered Machine Learning (HuM
We are looking for highly motivated researchers to join our group in interdisciplinary projects that focus on the development of computational models to understand how linguistic information is repres
The CSNG Lab at the Faculty of Mathematics and Physics at the Charles University is seeking a highly motivated Postdoctoral Researcher to join our team to work on a digital twin model of the visual sy
PROJECT SUMMARY / ABSTRACT Cluster headache (CH), which affects about 1 in 1,000 people, is a severe and debilitating primary headache disorder characterized by repeated attacks occurring in clusters