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UCL, UK
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Schedule
Wednesday, October 29, 2025
1:15 PM Europe/Zurich
Domain
NeuroscienceHost
NeuroLeman Network
Duration
70 minutes
The cortex comprises many neuronal types, which can be distinguished by their transcriptomes: the sets of genes they express. Little is known about the in vivo activity of these cell types, particularly as regards the structure of their spike trains, which might provide clues to cortical circuit function. To address this question, we used Neuropixels electrodes to record layer 5 excitatory populations in mouse V1, then transcriptomically identified the recorded cell types. To do so, we performed a subsequent recording of the same cells using 2-photon (2p) calcium imaging, identifying neurons between the two recording modalities by fingerprinting their responses to a “zebra noise” stimulus and estimating the path of the electrode through the 2p stack with a probabilistic method. We then cut brain slices and performed in situ transcriptomics to localize ~300 genes using coppaFISH3d, a new open source method, and aligned the transcriptomic data to the 2p stack. Analysis of the data is ongoing, and suggests substantial differences in spike time coordination between ET and IT neurons, as well as between transcriptomic subtypes of both these excitatory types.
Kenneth Harris
UCL, UK
neuro
Nervous system function relies on the polarized architecture of neurons, established by directional transport of pre- and postsynaptic cargoes. While delivery of postsynaptic components depends on the
neuro
A combinatorial neural code for long-term motor memory
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The postdoctoral researcher will work on an interdisciplinary project at the intersection of deep learning and comparative politics. The candidate will work in the Human-Centered Machine Learning (HuM
The CSNG Lab at the Faculty of Mathematics and Physics at the Charles University is seeking a highly motivated Postdoctoral Researcher to join our team to work on a digital twin model of the visual sy
We have an open position for a postdoctoral researcher with experience in brain-computer interfacing and artificial intelligence to further advance our new class of Brain-Artificial Intelligence (BAI)
PROJECT SUMMARY / ABSTRACT Cluster headache (CH), which affects about 1 in 1,000 people, is a severe and debilitating primary headache disorder characterized by repeated attacks occurring in clusters