Toward a Comprehensive Classification of Mouse Retinal Ganglion Cells: Morphology, Function, Gene Expression, and Central Projections
Schedule
Monday, June 29, 2020
15:00 UTC
Greg Schwartz
Prof.
Northwestern University, Feinberg School of Medicine
Host: Tubingen Neuro Campus
Recording
Open recording
Event Information
Recording
Available
Host
Tubingen Neuro Campus
Duration
70 minutes
Abstract
I will introduce a web portal for the retinal neuroscience community to explore the catalog of mouse retinal ganglion cell (RGC) types, including data on light responses, correspondences with morphological types in EyeWire, and gene expression data from single-cell transcriptomics. Our current classification includes 43 types, accounting for 90% of the cells in EyeWire. Many of these cell types have new stories to tell, and I will cover two of them that represent opposite ends of the spectrum of levels of analysis in my lab. First, I will introduce the “Bursty Suppressed-by-Contrast” RGC and show how its intrinsic properties rather than its synaptic inputs differentiate its function from that of a different well-known RGC type. Second, I will present the histogram of cell types that project to the Olivary Pretectal Nucleus, focusing on the recently discovered M6 ipRGC.
Topics
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