Topic: transcriptomics

Liver toxicity can emerge late in drug development when early assays fail to capture human biology, exposure or injury mechanisms. This webinar introduces Axiom’s hepatic profiling approach, combining multicellular liver systems, high-content imaging, transcriptomics, proteomics and ADME measurements. Its reasoning agent integrates those results with partner assays, chemical-series context, exposure estimates and clinical evidence to assess mechanistic liver-safety risks. Rather than using a single cell-toxicity score, the approach develops interpretable, series-specific structure–toxicity hyp

Two-year NSF-funded postdoctoral appointment in the P-MixSwitch collaboration with the University of Arizona. Investigate how marine mixoplankton switch between photosynthesis and predation using cultures, molecular experiments, transcriptomics and bioinformatics. Based in Selinsgrove, with one to two months annually in Tucson and an anticipated January 2027 start. Submit a cover letter, CV and three referee contacts through the employer’s online system by 15 October.

Exploration of genome organization and function in the HIV infected brain is critical to aid in the understanding and development of treatments for HIV-associated neurocognitive disorder (HAND). Here, we applied a multiomic approach, including single nuclei transcriptomics, cell-type specific Hi-C 3D genome mapping, and viral integration site sequencing (IS-seq) to frontal lobe tissue from HIV-infected individuals with encephalitis (HIVE) and without encephalitis (HIV+). We observed reorganization of open/repressive (A/B) compartment structures in HIVE microglia encompassing 6.4% of the genome

Abuse, neglect, and other forms of uncontrollable stress during childhood and early adolescence can lead to adverse outcomes later in life, including especially perturbations in the regulation of mood and emotional states, and specifically anxiety disorders and depression. However, stress experiences vary from one individual to the next, meaning that causal relationships and mechanistic accounts are often difficult to establish in humans. This interdisciplinary talk considers the value of research in experimental animals where stressor experiences can be tightly controlled and detailed investi

I will introduce a web portal for the retinal neuroscience community to explore the catalog of mouse retinal ganglion cell (RGC) types, including data on light responses, correspondences with morphological types in EyeWire, and gene expression data from single-cell transcriptomics. Our current classification includes 43 types, accounting for 90% of the cells in EyeWire. Many of these cell types have new stories to tell, and I will cover two of them that represent opposite ends of the spectrum of levels of analysis in my lab. First, I will introduce the “Bursty Suppressed-by-Contrast” RGC and s

In the last 500 million years, the dorsal telencephalon changed like no other region of the vertebrate brain. Differences range from the six-layered neocortex of mammals, to the small three-layered cortex of reptiles, and the complete absence of lamination in birds. These anatomical differences have prompted endless discussions on the origins and evolution of the cerebral cortex. We have approached this problem from a cell type and transcriptomics perspective. This reveals a more granular picture, where different cell types and classes have followed independent trajectories of evolutionary cha

Reliably identifying cell types is crucial for understanding neural systems (1). However, classifying the neurons recorded in large-scale population recordings into well-defined types remains a challenge. While some methods rely on genetic targeting or anatomy for classification, a functional approach used in sensory systems is to analyze neuronal responses to stimuli that elicit distinguishable responses across different types (2, 3, 4). Yet, previous approaches of this nature have been limited by a restricted set of stimuli and scalability issues, thus preventing comprehensive characterizati