Topic: Proteomics

Study molecular markers of vascular cognitive decline and resilience with Anna Marseglia and the Westman group. The project combines proteomics, neuroimaging, cognitive and clinical measures, lifestyle and genetic data from longitudinal cohorts including H70 and UK Biobank. Statistical and machine-learning analyses also address brain-age measures. This two-year full-time appointment is based at Karolinska’s Neo building on the Flemingsberg campus. Apply through the recruitment portal by 29 September 2026.

Parallel Squared Technology Institute is recruiting research associate and senior research associate candidates to operate and maintain mass spectrometers, prepare protein samples, manage reagents and samples, and analyze experimental data. The institute is developing high-throughput protein-analysis technology with initial applications in Alzheimer’s disease and aging.

Parallel Squared Technology Institute is hiring an experienced mass spectrometrist to operate and maintain instruments across vendors, optimize LC-MS/MS methods, design proteomics experiments, analyze data, and train colleagues. The work advances high-throughput protein analysis for disease mechanisms, including Alzheimer’s disease and aging.

Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases of humans and many animal species caused by prions. The main constituent of prions is PrPSc, an aggregated moiety of the host-derived membrane glycolipoprotein PrPC. Prions were found to encipher many phenotypic, genetically stable TSE variants. The latter is very surprising, since PrPC is encoded by the host genome and all prion strains share the same amino acid sequence. Here I will review what is known about the infectivity, the neurotoxicity, and the neuroinvasiveness of prions. Also, I will explain why I regar