Are mitochondria a missing link between arginase 2 loss and Huntington’s disease pathogenesis?
Martyna Podgajna, Magdalena Gewartowska, Aleksandra Kaczynska, Aleksandra Owczarek and 2 more
FENS Forum 2024
Arginase 2 (Arg2), an arginine-metabolizing, mitochondrial enzyme, has been recently found to be enriched in the striatum, and progressive loss of Arg2 has been proposed as a potential factor contributing to the pathogenesis of Huntington’s disease (HD), a disorder primarily involving this region of the brain.…