Neurodegeneration

…to circuits, behaviour and neurodegeneration. Programme themes cover neurodevelopmental and psychiatric disorders, ageing, human glia, glia-focused technologies, and interactions with immune cells and other glia. Talks, posters and extended discussion support exchange among established researchers and trainees. Applicants n

…in human neuropathology focused on neurodegeneration, with 80% time for independent research and 20% on the clinical neuropathology service. Experience in an Alzheimer's Disease Research Center setting, additional molecular and cellular approaches and translational research are valued, as are extramural funding or competitive applications for mentored or independent awards. The total negotiated salary u

…computational and data neuroscience, neurodegeneration, CNS injury, neuroimmunology, and sensory, motor and cognitive systems. Successful applicants will develop independent research, mentor trainees and contribute to teaching. Applications remain open until filled; the September priority-review date has passed, but the official posting continues to accept applications.

…The search spans neurodevelopment, neurodegeneration, neuroimmunology and cancer neuroscience, and is open at assistant, associate and full professor levels. Faculty contribute to research, teaching and collaborative scientific activity. The university states that applications will remain open until the positions are filled.

…intersection of biological aging and neurodegeneration; develops cellular, molecular, biochemical and imaging techniques to study brain aging; leads projects across cells, animal models, postmortem human tissue and clinical trials; works with clinicians, computational biologists and neuroscientists; mentors postdocs, graduate students and technicians; contributes to gra

…and examines their relevance to neurodegeneration, cancer, and other diseases.

…and how their breakdown contributes to neurodegeneration. The discussion moves beyond single explanations such as inflammation or waste clearance to a systems-level study of brain resilience. Clandinin describes a collaborative programme combining large-scale genetic perturbations in flies and mice with molecular, circuit and behavioural measurements. Computational models will connect these observations across cell types, predict interacti

Meagan McManus examines mitochondrial dysfunction as an early driver of brain ageing and neurodegeneration. Reactive oxygen species and other mitochondrial stress signals connect impaired energy metabolism with glial activation. The talk presents preclinical evidence for [18F]ROStrace PET, a redox-sensitive tracer that crosses the blood–brain barrier, as a non-invasive way to detect mitochondrial and immune distress before overt pathology in models relevant to late-onset Alzheimer’s and Parkinson’s diseases. Online via the University of Arizona Zoom meeting. Use the Zoom link published on the

Monther Abu-Remaileh examines the cell's recycling machinery and its possible role in neurodegeneration. He explains how lysosomes process cellular material, why failures in that system can affect neurons, and how studying this biology may reveal connections among protein accumulation, aging and brain disease.

…shown to significantly slow or prevent neurodegeneration, their reduced bioavailability and inability to penetrate the blood-brain-barrier limit their use as potential therapeutics. To bypass these limitations, our research team has developed and patented small-sized, lipophilic

Among all prevalent diseases with a central neurodegeneration, AMD can be considered the most promising in terms of prevention and early intervention, due to several factors surrounding the neural geometry of the foveal singularity. • Steep gradients of cell density, deployed in a radially symmetric fashion, can be modeled with a difference of Gaussian curves. • These steep gradients give rise to huge, spatially aligned biologic effects, summarized as the Center of Cone Resilience, Surround of Rod Vulnerability. • Widely used clinical imaging technology provides cellular and subcellular level

…being common early signs of neurodegeneration, in particular of Parkinson’s Disease (PD). Clinical research is currently challenging the assumption that human sleep is a one-fits-all phenomenon: breaking new grounds into sleep research is needed. In this scenario, the European Research Council PathFinder Open project NAP proposes a new science-toward-technology paradigm enabling the study of hu

…neurofibrillary tangles and excessive neurodegeneration. The mechanisms of neuron degeneration and the potential of these neurons to form new nerve fibers for compensation remain elusive. The present study aimed to evaluate the impact of beta-amyloid and tau on new formations of nerve fibers from mouse organotypic brain slices connected to collagen-based microcontact prints.Methods: Organotypic mouse brain slices of postnatal day 8-10 mice were connected to established collagen-based micro

We have recently established Rnaset2-/- mice as a model system to improve the pathophysiological understanding of infantile-onset RNaseT2-deficient leukoencephalopathies and type I interferonopathies. Rnaset2-/- mice were viable and healthy at birth, but displayed upregulation of type I interferon-stimulated genes in all organs examined. At 20 weeks of age, RNaseT2-deficient animals developed IFNAR1-dependent neuroinflammation, characterized primarily by the presence of CD8 T cells and inflammatory monocytes. Single nuclei transcriptome analyses revealed homeostatic dysfunction in glial cells

The gut microbiome plays an integral part in neurodegeneration through its direct interaction with the autonomic nervous system (ANS) via the vagal nerve. The aim of this pilot study is to investigate changes in ANS function in patients with mild Alzheimer’s Disease (AD) following administration of probiotics, compared to placebo (no active probiotics). Patients with mild AD (MMSE: 19-23) who fulfil all eligibility criteria were enrolled on the study and randomly assigned to take probiotics or placebo (control) for 16 weeks. We collected various data at baseline and study completion (weeks 0 &

…behavior, and memory activity, neurodegeneration, neuroinflammation, blood-brain barrier (BBB) integrity, cerebral glucose metabolism, and neurodegenerative progression

…that mimics many of the hallmarks of neurodegeneration seen in dementia but does no

Trimethyltin (TMT)-induced neurodegeneration leads to molecular and behavioral changes similar to those of Alzheimer's disease (AD). Continuous theta burst stimulation (cTBS) has shown promise in psychiatric and neurological disorders but remains largely unexplored in AD models. For this reason, a well-characterized animal model of TMT-induced hippocampal neurodegeneration was used to investigate, for the first time, the effects of cTBS on learning/memory and behavioral disturbances.Adult male Wistar rats were divided into four experimental groups: intact control, TMT (8mg/kg, ip) and TMT trea

Parkinson's disease (PD), as the most prevalent neurodegenerative motor disorder, presents a complex spectrum of symptoms encompassing both motor impairments (bradykinesia, resting tremor, freezing of gait) and non-motor manifestations (depression, anosmia, anxiety). Robust animal models that faithfully replicate this multifaceted pathology are indispensable for comprehensive PD research. This study aims to investigate if depressive-like behaviour, prominent in up to 40% of PD patients (Laux, 2022), emerges in the bilateral human mutated alpha-synuclein (A53T) rat model of PD.40 adult Sprague-

Preclinical research into dementia with Lewy bodies (DLB) is challenging due to the lack of α-synucleinopathy animal models that do not also develop Parkinsonism. To address this issue, we have developed a new mouse model for investigating the impact of α-synuclein (α-Syn) overexpression and aggregation on driving cortical and hippocampal circuit dysfunction. Using bilateral stereotaxic injections of adeno-associated virus (AAVs) vectors, we transduced overexpression of human SNCA (encoding α-Syn) with mScarlet (red fluorophore), or an mScarlet-only control vector. We targeted either dorsal hi

Pathological protein aggregation and synaptic dysfunction are major contributors to neurodegenerative disorders. However, understanding disease-relevant protein aggregation, such as Beta-amyloid, Alpha-synuclein and Tau aggregation within synapses, remains limited. To address this, we present a novel method for visualizing protein aggregates in individual synaptosomes. We combined Single-molecule Pull Down (SiMPull) and direct Stochastic Optical Reconstruction Microscopy (dSTORM), to immobilize individual synaptosomes and characterize single aggregates within them with ~20nm spatial resolution

Aging, both physiological and pathological, results in a widespread decline in cognitive, sensory, and motor functions. Adult hippocampal neurogenesis is a phenomenon that diminishes with age across various mammalian species and has been proposed as a significant factor linked to age-related cognitive deficits. Our laboratory's preliminary studies reveal that mice lacking the DREAM protein (dream -/-) exhibit cognitive improvement with aging, along with increased neurogenesis and greater development of immature neurons positive for DCX compared to wild-type mice of the same age. To further und

…subset in neuroinflammation and neurodegeneration, models to study and modify their neurotoxic phenotype are in increasing demand. Here we propose CD49f enriched human astrocytic U373 cells as a cost- and time-effective model to evaluate the metabolic and functional changes that reactive astrocytes undergo under pro-inflammatory con

Alzheimer’s disease (AD) is marked by amyloid beta accumulation, tau pathology, and cognitive decline. Sleep disturbances in AD are linked to amyloid beta, yet the influence of tau pathology on sleep remains unexplored. Using Drosophila melanogaster, we investigated adult-onset tau expression effects on sleep, addressing the knowledge gap in tauopathy's impact on sleep-related changes in AD progression. Pan-neuronal expression of wild-type tau and pseudo-phosphorylated tau E14 in Drosophila was induced in adult flies by RU 486 and activity and sleep were monitored in an automated Drosophila Ac