Zebrafish models help untangle genetic interactions in motor neuron degeneration

Due to high homology to the human genome and rapid development, zebrafish have been successfully used to
model diseases of the neuromuscular system. In this seminar, I will present current advances in modeling genetic
causes of Amyotrophic Lateral Sclerosis (ALS), the most common motor neuron degeneration and show how
epistatic interaction studies in zebrafish have helped elucidate synergistic effects of major ALS genes and their
cellular targets.