Applications are invited for a postdoctoral research associate to study visual learning and attention brain circuits in mice. The post is based in the lab of Dr Jasper Poort in the Department of Physiology, Development and Neuroscience at the University of Cambridge. The successful candidate will work on a research project funded by the Wellcome Trust that will investigate the neural circuit mechanisms of visual learning and attention (see Poort et al., Neuron 2015, Khan et al, Nature Neuroscience 2018, Poort et al, Neuron 2021). The project combines two-photon calcium imaging, electrophysiology and optogenetic manipulation of different cell types and neural projections in visual cortical areas and decision-making brain areas to understand how mice (including mouse models of neurodevelopmental disorders) learn to become experts in different visually-guided decision-making tasks and flexibly switch attention between tasks. The successful applicant will join a supportive and multi-disciplinary research environment and collaborate with experts on learning and attention in rodents and humans, experts on learning and attention impairments in mental disorders, and computational neuroscientists. Applicants should have completed (or are about to submit) a PhD (research associate) or (under)graduate degree (research assistant) in neuroscience, biology, engineering, or other relevant disciplines. We are looking for someone with previous experience in two-photon imaging/electrophysiology/optogenetics/pharmacology/histology and behavioural training in mice, and strong data analysis skills (e.g. Matlab or Python). The research position is available from Feb 2022 onwards for an initial 2 year period with the possibility for extension. For more information about the lab see https://www.pdn.cam.ac.uk/svl/. Apply here: https://www.jobs.cam.ac.uk/job/32860/ In addition to the cover letter, CV, and contact details of 2 references, applicants are asked to provide a brief statement (500 words) describing the questions and approach they consider important for the study of the neural circuits for learning and attention in mice and their future research ambitions. The closing date for applications is 15th January 2022. Informal enquiries about the position can be made to Jasper Poort (jp816@cam.ac.uk). References: Poort, Wilmes,Chadwick, Blot, Sahani, Clopath, Mrsic-Flogel, Hofer, Khan (2021). Learning and attention increase neuronal response selectivity in mouse primary visual cortex through distinct mechanisms. Neuron https://doi.org/10.1016/j.neuron.2021.11.016 Khan, Poort, Chadwick, Blot, Sahani, Mrsic-Flogel, Hofer (2018). Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex. Nature Neuroscience https://doi.org/10.1038/s41593-018-0143-z Poort, Khan, Pachitariu, Nemri, Orsolic, Krupic, Bauza, Sahani, Keller, Mrsic-Flogel, Hofer (2015). Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex. Neuron https://doi.org/10.1016/j.neuron.2015.05.037

The Lindsay Lab is looking for a post-doc to work on either of the first two research directions listed here: https://lindsay-lab.github.io/research/ (i.e. modeling attention with artificial neural networks or using ANNs to test methods from neuroscience). The post is funded for two years.

Applications are invited for a postdoctoral research associate to study visual learning and attention brain circuits in mice. The post is based in the lab of Dr Jasper Poort in the Department of Physiology, Development and Neuroscience at the University of Cambridge. The successful candidate will work on a research project funded by the Wellcome Trust that will investigate the neural circuit mechanisms of visual learning and attention (see Poort et al., Neuron 2015, Khan et al, Nature Neuroscience 2018, Poort et al, Neuron 2021). The project combines two-photon calcium imaging, electrophysiology and optogenetic manipulation of different cell types and neural projections in visual cortical areas and decision-making brain areas to understand how mice (including mouse models of neurodevelopmental disorders) learn to become experts in different visually-guided decision-making tasks and flexibly switch attention between tasks. The successful applicant will join a supportive and multi-disciplinary research environment and collaborate with experts on learning and attention in rodents and humans, experts on learning and attention impairments in mental disorders, and computational neuroscientists. Applicants should have completed (or are about to submit) a PhD (research associate) or (under)graduate degree (research assistant) in neuroscience, biology, engineering, or other relevant disciplines. We are looking for someone with previous experience in two-photon imaging/electrophysiology/optogenetics/pharmacology/histology and behavioural training in mice, and strong data analysis skills (e.g. Matlab or Python). The research position is available from Feb 2022 onwards for an initial 2 year period with the possibility for extension. For more information about the lab see https://www.pdn.cam.ac.uk/svl/. Apply here: https://www.jobs.cam.ac.uk/job/32860/ In addition to the cover letter, CV, and contact details of 2 references, applicants are asked to provide a brief statement (500 words) describing the questions and approach they consider important for the study of the neural circuits for learning and attention in mice and their future research ambitions. The closing date for applications is 15th January 2022. Informal enquiries about the position can be made to Jasper Poort (jp816@cam.ac.uk). References: Poort, Wilmes,Chadwick, Blot, Sahani, Clopath, Mrsic-Flogel, Hofer, Khan (2021). Learning and attention increase neuronal response selectivity in mouse primary visual cortex through distinct mechanisms. Neuron https://doi.org/10.1016/j.neuron.2021.11.016 Khan, Poort, Chadwick, Blot, Sahani, Mrsic-Flogel, Hofer (2018). Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex. Nature Neuroscience https://doi.org/10.1038/s41593-018-0143-z Poort, Khan, Pachitariu, Nemri, Orsolic, Krupic, Bauza, Sahani, Keller, Mrsic-Flogel, Hofer (2015). Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex. Neuron https://doi.org/10.1016/j.neuron.2015.05.037

Applications are invited for a postdoctoral research associate to study visual learning and attention brain circuits in mice. The post is based in the lab of Dr Jasper Poort in the Department of Physiology, Development and Neuroscience at the University of Cambridge. The successful candidate will work on a research project funded by the Wellcome Trust that will investigate the neural circuit mechanisms of visual learning and attention (see Poort et al., Neuron 2015, Khan et al, Nature Neuroscience 2018, Poort et al, Neuron 2021). The project combines two-photon calcium imaging, electrophysiology and optogenetic manipulation of different cell types and neural projections in visual cortical areas and decision-making brain areas to understand how mice (including mouse models of neurodevelopmental disorders) learn to become experts in different visually-guided decision-making tasks and flexibly switch attention between tasks. The successful applicant will join a supportive and multi-disciplinary research environment and collaborate with experts on learning and attention in rodents and humans, experts on learning and attention impairments in mental disorders, and computational neuroscientists. Applicants should have completed (or are about to submit) a PhD (research associate) or (under)graduate degree (research assistant) in neuroscience, biology, engineering, or other relevant disciplines. We are looking for someone with previous experience in two-photon imaging/electrophysiology/optogenetics/pharmacology/histology and behavioural training in mice, and strong data analysis skills (e.g. Matlab or Python). The research position is available from Feb 2022 onwards for an initial 2 year period with the possibility for extension. For more information about the lab see https://www.pdn.cam.ac.uk/svl/. Apply here: https://www.jobs.cam.ac.uk/job/32860/ In addition to the cover letter, CV, and contact details of 2 references, applicants are asked to provide a brief statement (500 words) describing the questions and approach they consider important for the study of the neural circuits for learning and attention in mice and their future research ambitions. The closing date for applications is 15th January 2022. Informal enquiries about the position can be made to Jasper Poort (jp816@cam.ac.uk). References: Poort, Wilmes,Chadwick, Blot, Sahani, Clopath, Mrsic-Flogel, Hofer, Khan (2021). Learning and attention increase neuronal response selectivity in mouse primary visual cortex through distinct mechanisms. Neuron https://doi.org/10.1016/j.neuron.2021.11.016 Khan, Poort, Chadwick, Blot, Sahani, Mrsic-Flogel, Hofer (2018). Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex. Nature Neuroscience https://doi.org/10.1038/s41593-018-0143-z Poort, Khan, Pachitariu, Nemri, Orsolic, Krupic, Bauza, Sahani, Keller, Mrsic-Flogel, Hofer (2015). Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex. Neuron https://doi.org/10.1016/j.neuron.2015.05.037

We are offering a fully funded PhD opportunity to examine the interplay between attention and decision-making in complex, naturalistic tasks using advanced electro-/magnetoencephalography (E/MEG) techniques. Strong quantitative skills will be advantageous for this project. The project will be co-supervised by Dr. Konstantinos Tsetsos (University of Bristol) and Professor Anina Rich (Macquarie University). The selected student will join a unique PhD cohort, as part of a cotutelle graduate program between the University of Bristol and Macquarie University.

The interdisciplinary M.Sc. Program in Cognitive Systems combines courses from neural/connectionist and symbolic Artificial Intelligence, Machine Learning, and Cognitive Psychology, to explore the fundamentals of perception, attention, learning, mental representation, and reasoning, in humans and machines. The M.Sc. Program is offered jointly by two public universities in Cyprus (the Open University of Cyprus and the University of Cyprus) and has been accredited by the national Quality Assurance Agency. The program is directed by academics from the participating universities, and courses are offered in English via distance learning by an international team of instructors.

The Department of Psychological and Brain Sciences at the University of Massachusetts, Amherst is inviting applications for a tenure track, academic year, faculty position at the Assistant Professor level in its Cognition and Cognitive Neuroscience Psychology program, starting in Fall 2024. We are seeking outstanding applicants with expertise in any area of cognitive psychology or cognitive neuroscience, including interdisciplinary fields connected to cognitive psychology, whose work complements and broadens existing strengths in our program. The program has current strengths in attention, decision-making, psycholinguistics, and mathematical modeling, with connections to our Behavioral Neuroscience, Clinical Psychology, Developmental Science, and Social Psychology programs. Across the university, our faculty have strong connections to Linguistics, Information and Computer Sciences, and Speech, Language, and Hearing Sciences, as well as the Initiative in Cognitive Science, the Computational and Social Science Institute, the Institute for Diversity Sciences, and the Institute for Applied Life Sciences.

The new research team NECTARINE at INRIA in Strasbourg / France aims to create a synergy between clinicians and scientists to develop new healthcare technologies. The team researchers collaborate closely with clinicians and choose their research focus along the clinical applications. Major scientific objectives are the development of advanced online- and offline simulations of neural activity on the macroscopic scale involving new numerical techniques for real-time computation and data-driven simulation dedicated to patient-specific modelling. The specific focus of the team's research is general anaesthesia, description of consciousness and attention and neurostimulation of patients suffering from mental disorders.

The School of Psychological Science, Birkbeck University of London is seeking 2 open-ended Lecturers (tenure track Assistant Professors) with a focus on computational modelling and psychological processes such as Cognitive Science or Computational Cognitive Neuroscience. The successful candidates will have an emerging research track record in all areas of cognitive neuroscience, particularly with practical experience of neuroimaging and fMRI, and/or cognitive science, including experimental cognitive psychology and computational modelling. Their research interests should align with the department's existing research themes: Perception, Attention, Action and Emotion; Cognitive Computational Modelling; Brain and Cognitive Development; and Health and Lived Experience.

This PhD subject focuses on the association between attention and spiking neural networks for defining new efficient AI models for embedded systems such as drones, robots and more generally autonomous systems. The thesis will take place between the LEAT research lab in Sophia-Antipolis and the INT institute in Marseille which both develop complementary approaches on bio-inspired AI from neuroscience to embedded systems design.

The Department of Psychology at The Pennsylvania State University, University Park, PA, invites applications for a full-time Assistant or Associate Professor of Cognitive Psychology with anticipated start date of August, 2025. Areas of specialization within cognitive psychology are open and may include (but are not limited to) such topics as cognitive control, creativity, computational approaches and modelling, motor control, language science, memory, attention, perception, and decision making. A record of collaboration is desirable for both ranks. Substantial collaboration opportunities exist within the department that align with the department’s cross-cutting research themes and across campus. Current faculty in the cognitive area are active in units including the Center for Language Sciences, the Social Life and Engineering Sciences Imaging Center, the Center for Healthy Aging, the Center for Brain, Behavior, and Cognition and the Applied Research Lab. Responsibilities of the Assistant or Associate Professor of Cognitive Psychology include maintaining a strong record of publications in top outlets. This position will include resident instruction at the undergraduate and graduate level and normal university service, based on the candidate’s qualifications. A Ph.D. in Psychology or related field is required by the appointment date for both ranks. Candidates for the tenure-track Assistant Professor of Cognitive Psychology position must have demonstrated ability as a researcher, scholar, and teacher in a relevant field and have evidence of growth in scholarly achievement. Duties will involve a combination of teaching, research, and service, based on the candidate’s qualifications. Candidates for the tenure-track Associate Professor of Cognitive Psychology position must have demonstrated excellence as a researcher, scholar, and teacher in a relevant field and have an established reputation in scholarly achievement. Duties will involve a combination of teaching, research, and service, based on the candidate’s qualifications. The ideal candidate will have a strong record of publications in top outlets and have a history of or potential for external funding. In addition, successful candidates must either have demonstrated a commitment to building an inclusive, equitable, and diverse campus community, or describe one or more ways they would envision doing so, given the opportunity. Review of applications will begin immediately and will continue until the position is filled. Interested candidates should submit an online application at Penn State’s Job Posting Board, and should upload the following application materials electronically: (1) a Cover letter of application, (2) Concise statements of research and teaching interests, (3) a CV and (4) three selected (re)prints. System limitations allow for a total of 5 documents (5mb per document) as part of your application. Please combine materials to meet the 5-document limit. In addition, please arrange to have three letters of recommendation sent electronically to PsychApplications@psu.edu with the subject line: “Cognitive Psychology” Questions regarding the application process can be emailed to PsychApplications@psu.edu and questions regarding the position can be sent to the search chair: cogsearch@psu.edu. The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms. We embrace individual uniqueness, foster a culture of inclusion that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusion as a core strength and an essential element of our public service mission. Penn State offers competitive benefits to full-time employees, including medical, dental, vision, and retirement plans, in addition to 75% tuition discounts (including for a spouse and dependent children up to the age of 26) and paid holidays.

Prof. Angela Yu recently moved from UCSD to TU Darmstadt as the Alexander von Humboldt AI Professor, and has a number of PhD and postdoc positions available in her growing “Computational Modeling of Intelligent Systems” research group. Applications are solicited from highly motivated and qualified candidates, who are interested in interdisciplinary research at the intersection of natural and artificial intelligence. Prof. Yu’s group uses mathematically rigorous and algorithmically diverse tools to understand the nature of representation and computations that give rise to intelligent behavior. There is a fair amount of flexibility in the actual choice of project, as long as the project excites both the candidate and Prof. Yu. For example, Prof. Yu is currently interested in investigating scientific questions such as: How is socio-emotional intelligence similar or different from cognitive intelligence? Is there a fundamental tradeoff, given the prevalence of autism among scientists and engineers? How can AI be taught socio-emotional intelligence? How are artificial intelligence (e.g. as demonstrated by large language models) and natural intelligence (e.g. as measured by IQ tests) similar or different in their underlying representation or computations? What roles do intrinsic motivations such as curiosity and computational efficiency play in intelligent systems? How can insights about artificial intelligence improve the understanding and augmentation of human intelligence? Are capacity limitations with respect to attention and working memory a feature or a bug in the brain? How can AI system be enhanced by attention or WM? More broadly, Prof. Yu’s group employs and develops diverse machine learning and mathematical tools, e.g. Bayesian statistical modeling, control theory, reinforcement learning, artificial NN, and information theory, to explain various aspects of cognition important for intelligence: perception, attention, decision-making, learning, cognitive control, active sensing, economic behavior, and social interactions. Participants who have experience with two or more of the technical areas, and/or one or more of the application areas, are highly encouraged to apply. As part of the Centre for Cognitive Science at TU Darmstadt, the Hessian AI Center, as well as the Computer Science Department, Prof. Yu’s group members are encouraged and expected to collaborate extensively with preeminent researchers in cognitive science and AI, both nearby and internationally. All positions will be based at TU Darmstadt, Germany. Starting dates for the positions are flexible. Salaries are commensurate with experience and expertise, and highly competitive with respect to U.S. and European standards. The working language in the group and within the larger academic community is English. Fluency in German is not required; the university provides free German lessons for interested scientific staff.

We invite applications for key roles in the TUNASBE project, funded by the Swiss SNSF, which aims to improve AI’s ability to understand human states, activities, and complex social behaviors in natural settings. The project focuses on interpreting non-verbal cues—such as gaze, gestures, and attention—through multi-task learning models that capture the subtleties of human interactions. The project will be supported by two PhD students and one postdoctoral researcher, to lead the design and development of computational models, focusing on gaze, attention, and multi-cue integration for human-centric computer vision analysis of social behaviors at the subject and scene levels in general settings.

Multiple PhD and postdoctoral positions are immediately available in Prof. Angela Yu's research group at TU Darmstadt. The group investigates the intersection of natural and artificial intelligence using mathematically rigorous approaches to understand the representations and computations underlying intelligent behavior. The research particularly addresses challenges of inferential uncertainty and opportunities of volitional control. The group employs diverse methodological tools including Bayesian statistical modeling, control theory, reinforcement learning, and information theory to develop theoretical frameworks explaining key aspects of cognition: perception, attention, decision-making, learning, cognitive control, active sensing, economic behavior, and social interactions.

Thalamic networks, at the core of thalamocortical and thalamosubcortical communications, underlie processes of perception, attention, memory, emotions, and the sleep-wake cycle, and are disrupted in mental disorders, including schizophrenia and autism. However, the underlying mechanisms of pathology are unknown. I will present novel evidence on key organizational principles, structural, and molecular features of thalamocortical networks, as well as critical thalamic pathway interactions that are likely affected in disorders. This data can facilitate modeling typical and abnormal brain function and can provide the foundation to understand heterogeneous disruption of these networks in sleep disorders, attention deficits, and cognitive and affective impairments in schizophrenia and autism, with important implications for the design of targeted therapeutic interventions

n the neurosciences the need for some 'overarching' theory is sometimes expressed, but it is not always obvious what is meant by this. One can perhaps agree that in modern science observation and experimentation is normally complemented by 'theory', i.e. the development of theoretical concepts that help guiding and evaluating experiments and measurements. A deeper discussion of 'brain theory' will require the clarification of some further distictions, in particular: theory vs. model and brain research (and its theory) vs. neuroscience. Other questions are: Does a theory require mathematics? Or even differential equations? Today it is often taken for granted that the whole universe including everything in it, for example humans, animals, and plants, can be adequately treated by physics and therefore theoretical physics is the overarching theory. Even if this is the case, it has turned out that in some particular parts of physics (the historical example is thermodynamics) it may be useful to simplify the theory by introducing additional theoretical concepts that can in principle be 'reduced' to more complex descriptions on the 'microscopic' level of basic physical particals and forces. In this sense, brain theory may be regarded as part of theoretical neuroscience, which is inside biophysics and therefore inside physics, or theoretical physics. Still, in neuroscience and brain research, additional concepts are typically used to describe results and help guiding experimentation that are 'outside' physics, beginning with neurons and synapses, names of brain parts and areas, up to concepts like 'learning', 'motivation', 'attention'. Certainly, we do not yet have one theory that includes all these concepts. So 'brain theory' is still in a 'pre-newtonian' state. However, it may still be useful to understand in general the relations between a larger theory and its 'parts', or between microscopic and macroscopic theories, or between theories at different 'levels' of description. This is what I plan to do.

Gaze shifts in humans serve to direct high-resolution vision provided by the fovea towards areas in the environment. Gaze can be considered a proxy for attention or indicator of the relative importance of different parts of the environment. In this talk, we discuss the development of generative models of human gaze in response to visual input. We discuss how such models can be learned, both using supervised learning and using implicit feedback as an agent interacts with the environment, the latter being more plausible in biological agents. We also discuss two ways such models can be used. First, they can be used to improve the performance of artificial autonomous systems, in applications such as autonomous navigation. Second, because these models are contingent on the human’s task, goals, and/or state in the context of the environment, observations of gaze can be used to infer information about user intent. This information can be used to improve human-machine and human robot interaction, by making interfaces more anticipative. We discuss example applications in gaze-typing, robotic tele-operation and human-robot interaction.

Fast periodic visual stimulation (FPVS) has emerged as a promising tool for assessing cognitive function in individuals with dementia. This technique leverages electroencephalography (EEG) to measure brain responses to rapidly presented visual stimuli, offering a non-invasive and objective method for evaluating a range of cognitive functions. Unlike traditional cognitive assessments, FPVS does not rely on behavioural responses, making it particularly suitable for individuals with cognitive impairment. In this talk I will highlight a series of studies that have demonstrated its ability to detect subtle deficits in recognition memory, visual processing and attention in dementia patients using EEG in the lab, at home and in clinic. The method is quick, cost-effective, and scalable, utilizing widely available EEG technology. FPVS holds significant potential as a functional biomarker for early diagnosis and monitoring of dementia, paving the way for timely interventions and improved patient outcomes.

Vulnerability to distraction varies across the general population and significantly affects one’s capacity to stay focused on and successfully complete the task at hand, whether at school, on the road, or at work. In this talk, I will begin by discussing how distractibility is typically assessed in the literature and introduce our innovative ERP approach to measuring it. Since distractibility is a cardinal symptom of ADHD, I will introduce its most widely used paper-and-pencil screening tool for the general population as external validation. Following that, I will present the Load Theory of Attention and explain how we used perceptual load to test the reliability of our neural marker of distractibility. Finally, I will highlight potential future applications of this marker in clinical and educational settings.

Lapses in attention are ubiquitous and, unfortunately, the cause of many tragic accidents. One potential solution may be to develop assistance systems which can use objective, physiological signals to monitor attention levels and predict a lapse in attention before it occurs. As it stands, it is unclear which physiological signals are the most reliable markers of inattention, and even less is known about how reliably they will work in a more naturalistic setting. My project aims to address these questions across two experiments: a lab-based experiment and a more ‘real-world’ experiment. In this talk I will present the findings from my lab experiment, in which we combined EEG and pupillometry to detect markers of inattention during two computerised sustained attention tasks. I will then present the methods for my second, more ‘naturalistic’ experiment in which we use the same methods (EEG and pupillometry) to examine whether these markers can still be extracted from noisier data.

Decades of research on understanding the mechanisms of attentional selection have focused on identifying the units (representations) on which attention operates in order to guide prioritized sensory processing. These attentional units fit neatly to accommodate our understanding of how attention is allocated in a top-down, bottom-up, or historical fashion. In this talk, I will focus on attentional phenomena that are not easily accommodated within current theories of attentional selection – the “attentional platypuses,” as they allude to an observation that within biological taxonomies the platypus does not fit into either mammal or bird categories. Similarly, attentional phenomena that do not fit neatly within current attentional models suggest that current models need to be revised. I list a few instances of the ‘attentional platypuses” and then offer a new approach, the Dynamically Weighted Prioritization, stipulating that multiple factors impinge onto the attentional priority map, each with a corresponding weight. The interaction between factors and their corresponding weights determines the current state of the priority map which subsequently constrains/guides attention allocation. I propose that this new approach should be considered as a supplement to existing models of attention, especially those that emphasize categorical organizations.

Humans and other animals approach reward and avoid punishment and pay attention to cues predicting these events. Such motivated behavior thus appears to be guided by value, which directs behavior towards or away from positively or negatively valenced outcomes. Moreover, it is facilitated by (top-down) salience, which enhances attention to behaviorally relevant learned cues predicting the occurrence of valenced outcomes. Using human neuroimaging, we recently separated value (ventral striatum, posterior ventromedial prefrontal cortex) from salience (anterior ventromedial cortex, occipital cortex) in the domain of liquid reward and punishment. Moreover, we investigated potential drivers of learned salience: the probability and uncertainty with which valenced and non-valenced outcomes occur. We find that the brain dissociates valenced from non-valenced probability and uncertainty, which indicates that reinforcement matters for the brain, in addition to information provided by probability and uncertainty alone, regardless of valence. Finally, we assessed learning signals (unsigned prediction errors) that may underpin the acquisition of salience. Particularly the insula appears to be central for this function, encoding a subjective salience prediction error, similarly at the time of positively and negatively valenced outcomes. However, it appears to employ domain-specific time constants, leading to stronger salience signals in the aversive than the appetitive domain at the time of cues. These findings explain why previous research associated the insula with both valence-independent salience processing and with preferential encoding of the aversive domain. More generally, the distinction of value and salience appears to provide a useful framework for capturing the neural basis of motivated behavior.

Electroencephalography (EEG) has been thoroughly studied for decades in psychiatry research. Yet its integration into clinical practice as a diagnostic/prognostic tool remains unachieved. We hypothesize that a key reason is the underlying patient's heterogeneity, overlooked in psychiatric EEG research relying on a case-control approach. We combine HD-EEG with normative modeling to quantify this heterogeneity using two well-established and extensively investigated EEG characteristics -spectral power and functional connectivity- across a cohort of 1674 patients with attention-deficit/hyperactivity disorder, autism spectrum disorder, learning disorder, or anxiety, and 560 matched controls. Normative models showed that deviations from population norms among patients were highly heterogeneous and frequency-dependent. Deviation spatial overlap across patients did not exceed 40% and 24% for spectral and connectivity, respectively. Considering individual deviations in patients has significantly enhanced comparative analysis, and the identification of patient-specific markers has demonstrated a correlation with clinical assessments, representing a crucial step towards attaining precision psychiatry through EEG.

Three studies conducted in the context of PhD work (UNIL) aimed at proving evidence to address the question of potential gender differences in trait anxiety and executive control biases on behavioral efficacy. In scope were male and female non-clinical samples of adult young age that performed non-emotional tasks assessing basic attentional functioning (Attention Network Test – Interactions, ANT-I), sustained attention (Test of Variables of Attention, TOVA), and visual recognition abilities (Object in Location Recognition Task, OLRT). Results confirmed the intricate nature of the relationship between gender and health trait anxiety through the lens of their impact on processing efficacy in males and females. The possibility of a gendered theory in trait anxiety biases is discussed.

Comprehending speech under acoustically challenging conditions is an everyday task that we can often execute with ease. However, accomplishing this requires the engagement of cognitive resources, such as auditory attention and working memory. The mechanisms that contribute to the robustness of speech comprehension are of substantial interest in the context of hearing mild to moderate hearing impairment, in which affected individuals typically report specific difficulties in understanding speech in background noise. Although hearing aids can help to mitigate this, they do not represent a universal solution, thus, finding alternative interventions is necessary. Given that age-related hearing loss (“presbycusis”) is inevitable, developing new approaches is all the more important in the context of aging populations. Moreover, untreated hearing loss in middle age has been identified as the most significant potentially modifiable predictor of dementia in later life. I will present research that has used a multi-methodological approach (fMRI, EEG, MEG and non-invasive brain stimulation) to try to elucidate the mechanisms that comprise the cognitive “last mile” in speech acousticallychallenging speech comprehension and to find ways to enhance them.

In the real world, object arrangement follows a number of rules. Some of the rules pertain to the spatial relations between objects and scenes (i.e., syntactic rules) and others about the contextual relations (i.e., semantic rules). Research has shown that violation of semantic rules influences interval timing with the duration of scenes containing such violations to be overestimated as compared to scenes with no violations. However, no study has yet investigated whether both semantic and syntactic violations can affect timing in the same way. Furthermore, it is unclear whether the effect of scene violations on timing is due to attentional or other cognitive accounts. Using an oddball paradigm and real-world scenes with or without semantic and syntactic violations, we conducted two experiments on whether time dilation will be obtained in the presence of any type of scene violation and the role of attention in any such effect. Our results from Experiment 1 showed that time dilation indeed occurred in the presence of syntactic violations, while time compression was observed for semantic violations. In Experiment 2, we further investigated whether these estimations were driven by attentional accounts, by utilizing a contrast manipulation of the target objects. The results showed that an increased contrast led to duration overestimation for both semantic and syntactic oddballs. Together, our results indicate that scene violations differentially affect timing due to violation processing differences and, moreover, their effect on timing seems to be sensitive to attentional manipulations such as target contrast.

We use rapid eye, head, and body movements to extract information from a new part of the visual scene upon each new gaze fixation. But the consequences of such visual actions go beyond their intended sensory outcomes. On the one hand, intrinsic consequences accompany movement preparation as covert internal processes (e.g., predictive changes in the deployment of visual attention). On the other hand, visual actions have incidental consequences, side effects of moving the sensory surface to its intended goal (e.g., global motion of the retinal image during saccades). In this talk, I will present studies in which we investigated intrinsic and incidental sensory consequences of visual actions and their sensorimotor functions. Our results provide insights into continuously interacting top-down and bottom-up sensory processes, and they reify the necessity to study perception in connection to motor behavior that shapes its fundamental processes.

Non-human great apes inform one another in ways that can seem very humanlike. Especially in the gestural domain, their behavior exhibits many similarities with human communication, meeting widely used empirical criteria for intentionality. At the same time, there remain some manifest differences. How to account for these similarities and differences in a unified way remains a major challenge. This presentation will summarise the arguments developed in a recent paper with Christophe Heintz. We make a key distinction between the expression of intentions (Ladyginian) and the expression of specifically informative intentions (Gricean), and we situate this distinction within a ‘special case of’ framework for classifying different modes of attention manipulation. The paper also argues that the attested tendencies of great ape interaction—for instance, to be dyadic rather than triadic, to be about the here-and-now rather than ‘displaced’—are products of its Ladyginian but not Gricean character. I will reinterpret video footage of great ape gesture as Ladyginian but not Gricean, and distinguish several varieties of meaning that are continuous with one another. We conclude that the evolutionary origins of linguistic meaning lie in gradual changes in not communication systems as such, but rather in social cognition, and specifically in what modes of attention manipulation are enabled by a species’ cognitive phenotype: first Ladyginian and in turn Gricean. The second of these shifts rendered humans, and only humans, ‘language ready’.

Trends in NeuroAI is a reading group hosted by the MedARC Neuroimaging & AI lab (https://medarc.ai/fmri). Title: SwiFT: Swin 4D fMRI Transformer Abstract: Modeling spatiotemporal brain dynamics from high-dimensional data, such as functional Magnetic Resonance Imaging (fMRI), is a formidable task in neuroscience. Existing approaches for fMRI analysis utilize hand-crafted features, but the process of feature extraction risks losing essential information in fMRI scans. To address this challenge, we present SwiFT (Swin 4D fMRI Transformer), a Swin Transformer architecture that can learn brain dynamics directly from fMRI volumes in a memory and computation-efficient manner. SwiFT achieves this by implementing a 4D window multi-head self-attention mechanism and absolute positional embeddings. We evaluate SwiFT using multiple large-scale resting-state fMRI datasets, including the Human Connectome Project (HCP), Adolescent Brain Cognitive Development (ABCD), and UK Biobank (UKB) datasets, to predict sex, age, and cognitive intelligence. Our experimental outcomes reveal that SwiFT consistently outperforms recent state-of-the-art models. Furthermore, by leveraging its end-to-end learning capability, we show that contrastive loss-based self-supervised pre-training of SwiFT can enhance performance on downstream tasks. Additionally, we employ an explainable AI method to identify the brain regions associated with sex classification. To our knowledge, SwiFT is the first Swin Transformer architecture to process dimensional spatiotemporal brain functional data in an end-to-end fashion. Our work holds substantial potential in facilitating scalable learning of functional brain imaging in neuroscience research by reducing the hurdles associated with applying Transformer models to high-dimensional fMRI. Speaker: Junbeom Kwon is a research associate working in Prof. Jiook Cha’s lab at Seoul National University. Paper link: https://arxiv.org/abs/2307.05916

Qualitative coding is the process of categorizing and labeling raw data to identify themes, patterns, and concepts within qualitative research. This process requires significant time, reflection, and discussion, often characterized by inherent subjectivity and uncertainty. Here, we explore the possibility to leverage large language models (LLM) to enhance the process and assist researchers with qualitative coding. LLMs, trained on extensive human-generated text, possess an architecture that renders them capable of understanding the broader context of a conversation or text. This allows them to extract patterns and meaning effectively, making them particularly useful for the accurate extraction and coding of relevant themes. In our current approach, we employed the chatGPT 3.5 Turbo API, integrating it into the qualitative coding process for data from the SWISS100 study, specifically focusing on data derived from centenarians' experiences during the Covid-19 pandemic, as well as a systematic centenarian literature review. We provide several instances illustrating how our approach can assist researchers with extracting and coding relevant themes. With data from human coders on hand, we highlight points of convergence and divergence between AI and human thematic coding in the context of these data. Moving forward, our goal is to enhance the prototype and integrate it within an LLM designed for local storage and operation (LLaMa). Our initial findings highlight the potential of AI-enhanced qualitative coding, yet they also pinpoint areas requiring attention. Based on these observations, we formulate tentative recommendations for the optimal integration of LLMs in qualitative coding research. Further evaluations using varied datasets and comparisons among different LLMs will shed more light on the question of whether and how to integrate these models into this domain.

In our daily lives, we perceive things as possessing a mind (e.g., people) or lacking one (e.g., shoes). Intriguingly, how much mind we attribute to people can vary, with real people perceived to have more mind than depictions of individuals, such as photographs. Drawing from a range of research methodologies, including naturalistic observation, mobile eye tracking, and surreptitious behavior monitoring, I discuss how various shades of mind influence human attention and behaviour. The findings suggest the novel concept that overt attention (where one looks) in real-life is fundamentally supported by covert attention (attending to someone out of the corner of one's eye).

Working memory is about the past but for the future. Adopting such a future-focused perspective shifts the narrative of working memory as a limited-capacity storage system to working memory as an anticipatory buffer that helps us prepare for potential and sequential upcoming behaviour. In my talk, I will present a series of our recent studies that have started to reveal emerging principles of a working memory that looks forward – highlighting, amongst others, how selective attention plays a vital role in prioritising internal contents for behaviour, and the bi-directional links between visual working memory and action. These studies show how studying the dynamics of working memory, selective attention, and action together paves way for an integrated understanding of how mind serves behaviour.

Sleep strongly affects synaptic strength, making it critical for cognition, especially learning and memory formation. Whether and how sleep deprivation modulates human brain physiology and cognition is poorly understood. Here we examined how overnight sleep deprivation vs overnight sufficient sleep affects (a) cortical excitability, measured by transcranial magnetic stimulation, (b) inducibility of long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity via transcranial direct current stimulation (tDCS), and (c) learning, memory, and attention. We found that sleep deprivation increases cortical excitability due to enhanced glutamate-related cortical facilitation and decreases and/or reverses GABAergic cortical inhibition. Furthermore, tDCS-induced LTP-like plasticity (anodal) abolishes while the inhibitory LTD-like plasticity (cathodal) converts to excitatory LTP-like plasticity under sleep deprivation. This is associated with increased EEG theta oscillations due to sleep pressure. Motor learning, behavioral counterparts of plasticity, and working memory and attention, which rely on cortical excitability, are also impaired during sleep deprivation. Our study indicates that upscaled brain excitability and altered plasticity, due to sleep deprivation, are associated with impaired cognitive performance. Besides showing how brain physiology and cognition undergo changes (from neurophysiology to higher-order cognition) under sleep pressure, the findings have implications for variability and optimal application of noninvasive brain stimulation.

Neurofeedback provides a feedback display which is linked with on-going brain activity and thus allows self-regulation of neural activity in specific brain regions associated with certain cognitive functions and is considered a promising tool for clinical interventions. Recent reviews of neurofeedback have stressed the importance of applying the “double-blind” experimental design where critically the patient is unaware of the neurofeedback treatment condition. An important question then becomes; is double-blind even possible? Or are subjects aware of the purposes of the neurofeedback experiment? – this question is related to the issue of how we assess awareness or the absence of awareness to certain information in human subjects. Fortunately, methods have been developed which employ neurofeedback implicitly, where the subject is claimed to have no awareness of experimental purposes when performing the neurofeedback. Implicit neurofeedback is intriguing and controversial because it runs counter to the first neurofeedback study, which showed a link between awareness of being in a certain brain state and control of the neurofeedback-derived brain activity. Claiming that humans are unaware of a specific type of mental content is a notoriously difficult endeavor. For instance, what was long held as wholly unconscious phenomena, such as dreams or subliminal perception, have been overturned by more sensitive measures which show that degrees of awareness can be detected. In this talk, I will discuss whether we will critically examine the claim that we can know for certain that a neurofeedback experiment was performed in an unconscious manner. I will present evidence that in certain neurofeedback experiments such as manipulations of attention, participants display residual degrees of awareness of experimental contingencies to alter their cognition.

Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) share similarities in pathology and clinical presentation and come under the umbrella term of Lewy body dementias (LBD). Fluctuating cognition is a key symptom in LBD and manifests as altered levels of alertness and attention, with a marked difference between best and worst performance. Cognition and alertness can change over seconds or minutes to hours and days of obtundation. Cognitive fluctuations can have significant impacts on the quality of life of people with LBD as well as potentially contribute to the exacerbation of other transient symptoms including, for example, hallucinations and psychosis as well as making it difficult to measure cognitive effect size benefits in clinical trials of LBD. However, this significant symptom in LBD is poorly understood. In my presentation I will discuss the phenomenology of cognitive fluctuations, how we can measure it clinically and limitations of these approaches. I will then outline the work of our group and others which has been focussed on unpicking the aetiological basis of cognitive fluctuations in LBD using a variety of imaging approaches (e.g. SPECT, sMRI, fMRI and EEG). I will then briefly explore future research directions.

Fastball is a novel, fast, passive biomarker of cognitive function, that uses cheap, scalable electroencephalography (EEG) technology. It is sensitive to early dementia; language, education, effort and anxiety independent and can be used in any setting including patients’ homes. It can capture a range of cognitive functions including semantic memory, recognition memory, attention and visual function. We have shown that Fastball is sensitive to cognitive dysfunction in Alzheimer’s disease and Mild Cognitive Impairment, with data collected in patients’ homes using low-cost portable EEG. We are now preparing for significant scale-up and the validation of Fastball in primary and secondary care.

Sex hormones are powerful neuromodulators of learning and memory. In rodents and nonhuman primates estrogen and progesterone influence the central nervous system across a range of spatiotemporal scales. Yet, their influence on the structural and functional architecture of the human brain is largely unknown. Here, I highlight findings from a series of dense-sampling neuroimaging studies from my laboratory designed to probe the dynamic interplay between the nervous and endocrine systems. Individuals underwent brain imaging and venipuncture every 12-24 hours for 30 consecutive days. These procedures were carried out under freely cycling conditions and again under a pharmacological regimen that chronically suppresses sex hormone production. First, resting state fMRI evidence suggests that transient increases in estrogen drive robust increases in functional connectivity across the brain. Time-lagged methods from dynamical systems analysis further reveals that these transient changes in estrogen enhance within-network integration (i.e. global efficiency) in several large-scale brain networks, particularly Default Mode and Dorsal Attention Networks. Next, using high-resolution hippocampal subfield imaging, we found that intrinsic hormone fluctuations and exogenous hormone manipulations can rapidly and dynamically shape medial temporal lobe morphology. Together, these findings suggest that neuroendocrine factors influence the brain over short and protracted timescales.

With the increasing use of automated face recognition (AFR) technologies, it is important to consider whether these systems not only perform accurately, but also equitability or without “bias”. Despite rising public, media, and scientific attention to this issue, the sources of bias in AFR are not fully understood. This talk will explore how human cognitive biases may impact our assessments of performance differentials in AFR systems and our subsequent use of those systems to make decisions. We’ll also show how, if we adjust our definition of what a “biased” AFR algorithm looks like, we may be able to create algorithms that optimize the performance of a human+algorithm team, not simply the algorithm itself.

What do nonhuman primates know about each other and their social environment, how do they allocate their attention, and what are the functional consequences of social decisions in natural settings? Addressing these questions is crucial to hone in on the co-evolution of cognition, social behaviour and communication, and ultimately the evolution of intelligence in the primate order. I will present results from field experimental and observational studies on free-ranging baboons, which tap into the cognitive abilities of these animals. Baboons are particularly valuable in this context as different species reveal substantial variation in social organization and degree of despotism. Field experiments revealed considerable variation in the allocation of social attention: while the competitive chacma baboons were highly sensitive to deviations from the social order, the highly tolerant Guinea baboons revealed a confirmation bias. This bias may be a result of the high gregariousness of the species, which puts a premium on ignoring social noise. Variation in despotism clearly impacted the use of signals to regulate social interactions. For instance, male-male interactions in chacma baboons mostly comprised dominance displays, while Guinea baboon males evolved elaborate greeting rituals that serve to confirm group membership and test social bonds. Strikingly, the structure of signal repertoires does not differ substantially between different baboon species. In conclusion, the motivational disposition to engage in affiliation or aggressiveness appears to be more malleable during evolution than structural elements of the behavioral repertoire; this insight is crucial for understanding the dynamics of social evolution.

When a neuron breaks silence, it can emit action potentials in a number of patterns. Some responses are so sudden and intense that electrophysiologists felt the need to single them out, labeling action potentials emitted at a particularly high frequency with a metonym – bursts. Is there more to bursts than a figure of speech? After all, sudden bouts of high-frequency firing are expected to occur whenever inputs surge. In this talk, I will discuss the implications of seeing the neural code as having three syllables: silences, spikes and bursts. In particular, I will describe recent theoretical and experimental results that implicate bursting in the implementation of top-down attention and the coordination of learning.

Cognitive science and cognitive neuroscience researchers have agreed that the replication of findings is important for establishing which ideas (or theories) are integral to the study of cognition across the lifespan. Recently, high-profile papers have called into question findings that were once thought to be unassailable. Much attention has been paid to how p-hacking, publication bias, and sample size are responsible for failed replications. However, much less attention has been paid to the fidelity by which researchers enact study protocols. Researchers conducting education or clinical trials are aware of the importance in fidelity – or the extent to which the protocols are delivered in the same way across participants. Nevertheless, this idea has not been applied to cognitive contexts. This seminar discusses factors that impact the replicability of findings alongside recent models suggesting that even small fidelity deviations have real impacts on the data collected.

Following the seminal structure mapping theory by Dedre Gentner, the process of mapping the corresponding structures of relations defining two analogs has been understood as a key component of analogy making. However, not without a merit, in recent years some semantic, pragmatic, and perceptual aspects of analogy mapping attracted primary attention of analogy researchers. For almost a decade, our team have been re-focusing on relational structure mapping, investigating its potential mechanisms across various analogy tasks, both abstract (semantically-lean) and more concrete (semantically-rich), using diverse methods (behavioral, correlational, eye-tracking, EEG). I will present the overview of our main findings. They suggest that structure mapping (1) consists of an incremental construction of the ultimate mental representation, (2) which strongly depends on working memory resources and reasoning ability, (3) even if as little as a single trivial relation needs to be represented mentally. The effective mapping (4) is related to the slowest brain rhythm – the delta band (around 2-3 Hz) – suggesting its highly integrative nature. Finally, we have developed a new task – Graph Mapping – which involves pure mapping of two explicit relational structures. This task allows for precise investigation and manipulation of the mapping process in experiments, as well as is one of the best proxies of individual differences in reasoning ability. Structure mapping is as crucial to analogy as Gentner advocated, and perhaps it is crucial to cognition in general.

Temporal predictions are fundamental instruments for facilitating sensory selection, allowing humans to exploit regularities in the world. Recent evidence indicates that the motor system instantiates predictive timing mechanisms, helping to synchronize temporal fluctuations of attention with the timing of events in a task-relevant stream, thus facilitating sensory selection. Accordingly, in the auditory domain auditory-motor interactions are observed during perception of speech and music, two temporally structured sensory streams. I will present a behavioral and neurophysiological account for this theory and will detail the parameters governing the emergence of this auditory-motor coupling, through a set of behavioral and magnetoencephalography (MEG) experiments.

Behavioral studies have demonstrated that certain task features reliably enhance classification performance for challenging visual stimuli. These include extended image presentation time and the valid cueing of attention. Here, I will show how convolutional neural networks can be used as a model of the visual system that connects neural activity changes with such performance changes. Specifically, I will discuss how different anatomical forms of recurrence can account for better classification of noisy and degraded images with extended processing time. I will then show how experimentally-observed neural activity changes associated with feature attention lead to observed performance changes on detection tasks. I will also discuss the implications these results have for how we identify the neural mechanisms and architectures important for behavior.

Cognitive control guides behavior by controlling what, where, and how information is represented in the brain. Perhaps the most well-studied form of cognitive control has been ‘attention’, which controls how external sensory stimuli are represented in the brain. In contrast, the neural mechanisms controlling the selection of representations held ‘in mind’, in working memory, are unknown. In this talk, I will present evidence that the prefrontal cortex controls working memory by selectively enhancing and transforming the contents of working memory. In particular, I will show how the neural representation of the content of working memory changes over time, moving between different ‘subspaces’ of the neural population. These dynamics may play a critical role in controlling what and how neural representations are acted upon.

In popular media, there is often a connection drawn between the advent of awareness in artificial agents and those same agents simultaneously achieving human or superhuman level intelligence. In this talk, I will examine the validity and potential application of this seemingly intuitive link between consciousness and intelligence. I will do so by examining the cognitive abilities associated with three contemporary theories of conscious function: Global Workspace Theory (GWT), Information Generation Theory (IGT), and Attention Schema Theory (AST), and demonstrating that all three theories specifically relate conscious function to some aspect of domain-general intelligence in humans. With this insight, we will turn to the field of Artificial Intelligence (AI) and find that, while still far from demonstrating general intelligence, many state-of-the-art deep learning methods have begun to incorporate key aspects of each of the three functional theories. Given this apparent trend, I will use the motivating example of mental time travel in humans to propose ways in which insights from each of the three theories may be combined into a unified model. I believe that doing so can enable the development of artificial agents which are not only more generally intelligent but are also consistent with multiple current theories of conscious function.

Relational thinking involves comparing abstract relationships between mental representations that vary in complexity; however, this complexity is rarely made explicit during everyday comparisons. This study explored how people naturally navigate relational complexity and interference using a novel relational match-to-sample (RMTS) task with both minimal and relationally directed instruction to observe changes in performance across three levels of relational complexity: perceptual, analogy, and system mappings. Individual working memory and relational abilities were examined to understand RMTS performance and susceptibility to interfering relational structures. Trials were presented without practice across four blocks and participants received feedback after each attempt to guide learning. Experiment 1 instructed participants to select the target that best matched the sample, while Experiment 2 additionally directed participants’ attention to same and different relations. Participants in Experiment 2 demonstrated improved performance when solving analogical mappings, suggesting that directing attention to relational characteristics affected behavior. Higher performing participants—those above chance performance on the final block of system mappings—solved more analogical RMTS problems and had greater visuospatial working memory, abstraction, verbal analogy, and scene analogy scores compared to lower performers. Lower performers were less dynamic in their performance across blocks and demonstrated negative relationships between analogy and system mapping accuracy, suggesting increased interference between these relational structures. Participant performance on RMTS problems did not change monotonically with relational complexity, suggesting that increases in relational complexity places nonlinear demands on working memory. We argue that competing relational information causes additional interference, especially in individuals with lower executive function abilities.

SES neuroscience, using imaging and other methods, has revealed generalizations of interest for population neuroscience and the study of individual differences. But beyond its scientific interest, SES is a topic of societal importance. Does neuroscience offer any useful insights for promoting socioeconomic justice and reducing the harms of poverty? In this talk I will use research from my own lab and others’ to argue that SES neuroscience has the potential to contribute to policy in this area, although its application is premature at present. I will also attempt to forecast the ways in which practical solutions to the problems of poverty may emerge from SES neuroscience. Bio: Martha Farah has conducted groundbreaking research on face and object recognition, visual attention, mental imagery, and semantic memory and - in more recent times - has been at the forefront of interdisciplinary research into neuroscience and society. This deals with topics such as using fMRI for lie detection, ethics of cognitive enhancement, and effects of social deprivation on brain development.

Proper development of the nervous system depends not only on the inherited DNA sequence, but also on proper regulation of gene expression, as controlled in part by epigenetic mechanisms present in the parental gametes. In this presentation an internationally recognized research advocate explains why researchers concerned about the origins of increasingly prevalent neurodevelopmental disorders such as autism and attention deficit hyperactivity disorder should look beyond genetics in probing the origins of dysregulated transcription of brain-related genes. The culprit for a subset of cases, she contends, may lie in the exposure history of the parents, and thus their germ cells. To illustrate how environmentally informed, nongenetic dysfunction may occur, she focuses on the example of parents' histories of exposure to common agents of modern inhalational anesthesia, a highly toxic exposure that in mammalian models has been seen to induce heritable neurodevelopmental abnormality in offspring born of exposed germline.

Humans, as a social species, have an increased ability to detect and perceive visual elements involved in social exchanges, such as faces and eyes. The gaze, in particular, conveys information crucial for social interactions and social cognition. Researchers have hypothesized that in order to engage in dynamic face-to-face communication in real time, our brains must quickly and automatically process the direction of another person's gaze. There is evidence that direct gaze improves face encoding and attention capture and that direct gaze is perceived and processed more quickly than averted gaze. These results are summarized as the "direct gaze effect". However, in the recent literature, there is evidence to suggest that the mode of visual information processing modulates the direct gaze effect. In this presentation, I argue that top-down processing, and specifically the relevance of eye features to the task, promotes the early preferential processing of direct versus indirect gaze. On the basis of several recent evidences, I propose that low task relevance of eye features will prevent differences in eye direction processing between gaze directions because its encoding will be superficial. Differential processing of direct and indirect gaze will only occur when the eyes are relevant to the task. To assess the implication of task relevance on the temporality of cognitive processing, we will measure event-related potentials (ERPs) in response to facial stimuli. In this project, instead of typical ERP markers such as P1, N170 or P300, we will measure lateralized ERPs (lERPS) such as lateralized N170 and N2pc, which are markers of early face encoding and attentional deployment respectively. I hypothesize that the relevance of the eye feature task is crucial in the direct gaze effect and propose to revisit previous studies, which had questioned the existence of the direct gaze effect. This claim will be illustrate with different past studies and recent preliminary data of my lab. Overall, I propose a systematic evaluation of the role of top-down processing in early direct gaze perception in order to understand the impact of context on gaze perception and, at a larger scope, on social cognition.

Extensive research on science teaching has shown the effectiveness of analogies as a didactic tool which, when appropriately and effectively used, facilitates the learning process of abstract concepts. This seminar does not contradict the efficacy of such a didactic use of analogies in this seminar but switches attention and interest on their heuristic use in approaching and understanding of what previously unknown. Such a use of analogies derives from research with 10 to 17 year-olds, who, when asked to make predictions in novel situations and to then provide explanations about these predictions, they self-generated analogies and used them by reasoning on their basis. This heuristic use of analogies can be used in science teaching in revealing how students approach situations they have not considered before as well as the sources they draw upon in doing so.

The free-energy principle and active inference have received a significant attention in the fields of neuroscience and machine learning. However, it remains to be established whether active inference is an apt explanation for any given neural network that actively exchanges with its environment. To address this issue, we show that a class of canonical neural networks of rate coding models implicitly performs variational Bayesian inference under a well-known form of partially observed Markov decision process model (Isomura, Shimazaki, Friston, Commun Biol, 2022). Based on the proposed theory, we demonstrate that canonical neural networks—featuring delayed modulation of Hebbian plasticity—can perform planning and adaptive behavioural control in the Bayes optimal manner, through postdiction of their previous decisions. This scheme enables us to estimate implicit priors under which the agent’s neural network operates and identify a specific form of the generative model. The proposed equivalence is crucial for rendering brain activity explainable to better understand basic neuropsychology and psychiatric disorders. Moreover, this notion can dramatically reduce the complexity of designing self-learning neuromorphic hardware to perform various types of tasks.

During perception the visual system integrates current sensory evidence with previously acquired knowledge of the visual world. Presumably this computation relies on internal recurrent interactions. We record populations of neurons from the primary visual cortex of cats and macaque monkeys and find evidence for adaptive internal responses to structured stimulation that change on both slow and fast timescales. In the first experiment, we present abstract images, only briefly, a protocol known to produce strong and persistent recurrent responses in the primary visual cortex. We show that repetitive presentations of a large randomized set of images leads to enhanced stimulus encoding on a timescale of minutes to hours. The enhanced encoding preserves the representational details required for image reconstruction and can be detected in post-exposure spontaneous activity. In a second experiment, we show that the encoding of natural scenes across populations of V1 neurons is improved, over a timescale of hundreds of milliseconds, with the allocation of spatial attention. Given the hierarchical organization of the visual cortex, contextual information from the higher levels of the processing hierarchy, reflecting high-level image regularities, can inform the activity in V1 through feedback. We hypothesize that these fast attentional boosts in stimulus encoding rely on recurrent computations that capitalize on the presence of high-level visual features in natural scenes. We design control images dominated by low-level features and show that, in agreement with our hypothesis, the attentional benefits in stimulus encoding vanish. We conclude that, in the visual system, powerful recurrent processes optimize neuronal responses, already at the earliest stages of cortical processing.

Executive functions refer to a collection of mental processes such as attention, planning and problem solving, supported by a frontoparietal distributed brain network. These functions are essential for everyday life. Specifically in the context of patients with brain tumours there is a need to preserve them in order to enable good quality of life for patients. During surgeries for the removal of a brain tumour, the aim is to remove as much as possible of the tumour and at the same time prevent damage to the areas around it to preserve function and enable good quality of life for patients. In many cases, functional mapping is conducted during an awake surgery in order to identify areas critical for certain functions and avoid their surgical resection. While mapping is routinely done for functions such as movement and language, mapping executive functions is more challenging. Despite growing recognition in the importance of these functions for patient well-being in recent years, only a handful of studies addressed their intraoperative mapping. In the talk, I will present our new approach for mapping executive function areas using electrocorticography during awake brain surgery. These results will be complemented by neuroimaging data from healthy volunteers, directed at reliably localizing executive function regions in individuals using fMRI. I will also discuss more broadly challenges ofß using neuroimaging for neurosurgical applications. We aim to advance cross-modality neuroimaging of cognitive function which is pivotal to patient-tailored surgical interventions, and will ultimately lead to improved clinical outcomes.