Metaplasticity
metaplasticity
Dr. Gabriele Scheler
We are offering a research stipend to investigate theories of memorization in neural plasticity. The focus is a critical evaluation of the role of LTP/LTD and synaptic plasticity in memory. This position is virtual and could be done part-time, or full-time for three months. The ideal candidate should have solid knowledge of neurobiology, especially plasticity mechanisms, excellent communication skills, interest and enthusiasm for next-generation neural theories, a good understanding of computation and mathematics. Programming skills are not required for this position. Detailed knowledge of one area of neural plasticity, such as synapses, intracellular pathways or genetics, is expected. Further information available on request.
Synapses, Shadows and Stress Contagion
Survival is predicated on the ability of an organism to respond to stress. The reliability of this response is ensured by a synaptic architecture that is relatively inflexible (i.e. hard-wired). Our work has shown that in naive animals, synapses on CRH neurons in the paraventricular nucleus of the hypothalamus are very reluctant to modification. If animals are stressed, however, these synapses become willing to learn. This seminar will focus on mechanisms linking acute stress to metaplastic changes at glutamate synapses, and also show how stress, and these synaptic changes can be transmitted from one individual to another.
Dissecting the Factors of Metaplasticity with Meta-Continual Learning
COSYNE 2022
Modelling rTMS-Induced Metaplasticity Dynamics within Macroscopic Oscillatory Brain Circuits
Neuromatch 5