Topic: 2-photon calcium imaging

Natural visual environments are full of complex and diverse patterns. Recent neurophysiological experiments based on artificial patterns have suggested that macaque V1 neurons’ receptive fields are more complex and diverse in feature selectivity (Tang et al 2017) rather than just oriented Gabor filters. However, that finding was based on extensive parametric artificial stimuli used and might be biased. Hence, the nature of the neural codes of macaque V1 neurons remains controversial. To resolve this question, we performed 2-photon calcium imaging on three macaque monkeys to obtain 1689 V1 neur

The hippocampus creates a cognitive map of the world to optimize predictions and guide behavior, with the dorsal and ventral hippocampus believed to play unique roles in this process. To understand how such representations evolve with learning and are updated with new experience, we used 2-photon calcium imaging to track the same dCA1 or vCA1 neurons across days as mice learned to associate odor stimuli with different outcomes. During reward (sucrose) associative learning, we find that, initially, odor cues elicited robust responses in dCA1, whereas in vCA1 encoding of odor identity was reduce