Topic: 3,3'-iminodipropionitrile

In response to chronic stress, mammalian vestibular hair cells (HC) may undergo extrusion from the sensory epithelium. Before HC loss begins, the early damage is characterized by synaptic uncoupling and dismantlement of the calyceal junction, the cell adhesion complex formed between type I HCs and calyx afferents. This early pathology associates with the early loss of vestibular function, and both the initial epithelial and functional alterations are reversible. This study was aimed at identifying key gene expression responses associated with these phenomena. We used three animal models of chr

The sense of orientation in space is crucial for survival and navigation in the environment. The brain derives spatial orientation from (1) self-motion signals originating in the vestibular system of the inner ear and (2) visual signals encoding orientation relative to external landmarks. Previous studies in animal models have shown that spatial orientation is compromised after vestibular lesions, but the relationship between partial lesions and the degree of functional impairment has not been established.In the present study, navigation and spatial orientation capacities were tested in a modi