Topic: 5-HT1A receptor

While current antidepressants tackle depressive symptoms, they often fall short in addressing cognitive deficits associated with depression. Expanding upon our previous study on HBK-10, a multimodal compound targeting 5-HT1A receptors and demonstrating antidepressant-like properties, we now aim to investigate its procognitive potential and the underlaying mechanisms.First, we evaluated the influence of HBK-10 on ß-arrestin recruitment using CHO-K1 cells expressing the 5-HT1Areceptor. Subsequently, we conducted the Morris water maze test, employing the NMDA receptor antagonist MK-801 to induce

Major Depressive Disorder (MDD) is a prevalent psychiatric disorder, affecting approximately 280 million people worldwide (WHO, 2023). Most research on depression has focused only on neurons. However, astrocytes respond to neurotransmitter release from nearby neurons by elevating internal calcium levels and subsequent release of neuroactive transmitters, including ATP, D-serine, and GABA. These substances can then modulate synaptic activity. Although serotonin (5-HT) has been hypothesized to play a role in the development and manifestation of depression for decades, the precise mechanisms that