ePoster · Computational Neuroscience
Psychedelic space of neuronal population activity: emerging and disappearing contrastive dimensions
Dirk Goldschmitt, Bradley Dearnley, Clare Howarth, Jason Berwick, Li Su, Michael Okun · Bernstein Conference 2024
Psychedelics (5-HT2AR agonists) show great promise in treating mental disorders but their effects on neuronal population activity are not clear. Latent dimensions identified by Principal Component Analysis (PCA) capture the dynamics of this interrelated neuronal population activity. We asked whether latent dimensions emerge or disappear as a result of psychedelic administration (acute), and across other naturally occurring brain state transitions (sleep, arousal). Contrastive PCA (cPCA) [Abid et al. (2018), Nature Comm.] was applied to spontaneous brain activity recordings in rodents before