Topic: 8-arm radial maze

This study focused on unilateral spatial neglect (USN), a disorder of attention on the contralateral side caused by damage to the cerebral hemispheres. Existing evidence-based rehabilitation for USN is insufficient, prompting the need for an animal model to develop effective treatments. The study aims to establish an aged mouse model of USN targeting the medial agranular cortex, analogous to the human frontal eye field. Focal infarcts were induced in aged mice using photothrombosis, and USN was assessed in an 8-arm radial maze. Mice were given 11 minutes to freely explore the 8-arm radial maze

Depression is a serious mental illness that includes both behavioral symptoms and cognitive dysfunction. With the growing problem of ineffective treatment, there is a constant need for compounds with rapid antidepressant and procognitive effects. A compound that has shown antidepressant-like activity after single administration in animal models is NLX-101. NLX-101 preferentially activates postsynaptic 5-HT1A heteroreceptors in the prefrontal cortex, stimulating extracellular signal-regulated kinase (ERK1/2) phosphorylation. Thus, this study aimed to evaluate the potential ability of NLX-101 to