Topic: A1R

Pregnant women at risk of premature labor receive a single treatment with the synthetic glucocorticoid dexamethasone (DEX) between the 24th and 34th week of pregnancy to ensure adequate maturation of the fetal organs. Due to the postponement of the due date, several doses are often administered. Because purinergic signaling plays an important role in the development of the auditory brainstem, particularly the cochlear nucleus, we investigated whether repeated DEX treatments affect components of the ADP-mediated (NTPDase2 and P2Y1R) and adenosinergic (CD73 and A1R) signaling systems. To compare

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to reduced striatal dopamine and motor and non-motor symptoms. The imbalance of adenosine signaling plays a role in the pathogenesis of PD, particularly through increased A2AR and reduced A1R activity affecting D2R and D1R signaling pathways, respectively. This imbalance interferes with the reciprocal modulation of adenylate cyclase by A1R/D1R and A2AR/D2R and impairs motor control. Despite existing treatment options, there is an unmet need for new interve