Glucocorticoid receptors in astrocytes regulate alpha-synuclein pathological actions impacting motor and non-motor symptomatology of Parkinson's disease
Chaperon Agnès, Anne-Claire Compagnion, Cécile Vernochet, Soumee Bhattacharya, Anna Poysti, Ramita Anand, Emanuel Brouillet, François Tronche, Sébastien Parnaudeau, Alexis Bemelmans, Sheela Vyas · FENS Forum 2024
Our research is focused on the role of stress, mediated by glucocorticoids (GCs) acting through its receptor GR, in the pathogenesis of Parkinson’s disease (PD). PD is characterized by motor and non-motor symptoms. GC-GRs not only regulate inflammation but also profoundly modulate mood and cognition. Whether GR functions in glial cells affects mood and cognition in PD is not known. To examine the role of astrocyte GC-GR in PD pathogenesis, we are using mice in which GR gene can be conditionally and specifically inactivated in astrocytes and where we produce region-specific alpha-synuclein path
ePoster · Neuroscience