Topic: absence epilepsy

The default mode network`s (DMN) can be investigated using default EEG reactivity (DER).The default oscillatory macrostate (DEM) is exemplified by the macrostate showing thehighest decrease in occurrence probability during intermittent photic stimulation (IPS).This study aimed to investigate DER, in the deeply sedated epileptic brain.We used a genetic rat model of absence epilepsy, the adult Wistar Albino Glaxo Rijwijk(WAG/Rij) rat. Controls consisted of age-matched Wistar rats.Deep aesthetic coma was induced by chloral hydrate. We performed cortical EEG recordingsduring the induced altered st

The lateral hypothalamus produces the neuropeptides orexin-A and -B, also referred to as hypocretin-1 and -2, which activate the OX1 and OX2 receptors. The orexin system is linked to various neurobiological processes and specifically plays a critical role in regulating the sleep-wake cycle. Epilepsy, as a frequent neurological disease, affects people of all ages. Given that epilepsy can impact sleep in multiple ways, the relationship between the orexinergic system and the pathophysiology of generalized epilepsies remains to be determined.We investigated the orexin-type 2 receptor (OX2R) in the

P/Q-type calcium channels, also known as CaV2.1, are voltage-gated Ca2+ channels (VGCCs) enriched at many central synapses where they control neurotransmitter release. Loss-of-function mutations in CACNA1A, the gene encoding the pore-forming α1 subunit of CaV2.1, underlie several neurological disorders, including episodic ataxia type II (EA2) and absence epilepsy.Despite the existence of several experimental models, the etiology of these diseases still remains poorly understood, preventing the development of effective therapeutic strategies.Here, we have developed a CRISPR/Cas9-mediated strate

Spike-wave-discharges (SWD) are the electrophysiological hallmark of absence epilepsy. The leading theory on SWD generation suggests a seizure onset-zone in the deep somatosensory cortex (S1) with 5-9Hz oscillations often preceding SWDs (preictally). These may act as biomarkers, priming distant cortical regions, with the involvement of the centromedian thalamic nucleus (CM). However, these oscillations are also observed interictally. Our study aimed to characterize preictal and interictal 5-9Hz oscillations, exploring power variations across brain-regions. Additionally, we investigated if inte