Topic: acquired epilepsy

Leucine-rich glioma inactivated 1 (LGI1) is a soluble secreted protein which links Adam22/23 proteins across the synaptic cleft and is also abundant in the axon initial segments of in the hippocampus. Anti-LGI1 autoantibodies have been found in CSF and serum of acquired epilepsy patients with symptoms of limbic encephalitis with amnesia and seizures. Previous studies showed human LGI1 autoantibodies co-precipitated with voltage-gated (VG) potassium channel complexes in rodent tissue. As VG-ion channels help maintain homeostasis in hippocampal action potentials, dysregulation of these channels

Stroke is one of the main reasons of acquired epilepsy in adults. Little is known about the underlying pathomechanisms that occur during epileptogenesis, so between the transient hypoxia and the first late seizure.Some transcription factors drive gene-expression towards an epileptogenic phenotype through channelopathies, which may be acquired through brain insults, such as the T-type Ca2+ channel CaV3.2.Hypoxia-inducible factor 1α (HIF-1α) is quickly activated and can bind to the promoter of CaV3.2, potentially inducing an epileptogenic cascade in penumbra neurons.We used NS20Y cells and prima