Topic: actin reorganization

We previously reported that TRPV2 can be activated by mechanical stimulation which enhances axonal outgrowth in developing neurons (Shibasaki et al., J. Neurosci. 2010). However, the molecular mechanisms governing the contribution of TRPV2 activation to axonal outgrowth remain unclear. In this study, we examined this mechanism. Overexpression of TRPV2 enhanced axonal outgrowth in a mechanical stimulus-dependent manner. Accumulation of TRPV2 at the cell surface was 4-fold greater in the growth cone compared to the soma. In the growth cone, TRPV2 is not static, but dynamically accumulates (withi

Neural network formation throughout development and regeneration after injury depends on accuracy of axonal pathfinding, which is influenced by chemical and physical cues. Recently, there is growing evidence that local temperature fluctuations in the brain play a crucial role in axonal guidance. However, the precise mechanisms involved in this process are not completely understood. We hypothesize that spontaneous and trauma-induced axon growth is repelled by increasing nanoscale temperature gradients leading to growth inhibition and growth cone retraction. Transient receptor potential vanilloi